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The genetic basis of gout
The genetic basis of gout
- Source :
- Rheumatic diseases clinics of North America. 40(2)
- Publication Year :
- 2014
-
Abstract
- Gout results from deposition of monosodium urate (MSU) crystals. Elevated serum urate concentrations (hyperuricemia) are not sufficient for the development of disease. Genome-wide association studies (GWAS) have identified 28 loci controlling serum urate levels. The largest genetic effects are seen in genes involved in the renal excretion of uric acid, with others being involved in glycolysis. Whereas much is understood about the genetic control of serum urate levels, little is known about the genetic control of inflammatory responses to MSU crystals. Extending knowledge in this area depends on recruitment of large, clinically ascertained gout sample sets suitable for GWAS.
- Subjects :
- musculoskeletal diseases
medicine.medical_specialty
Gout
Genome-wide association study
Disease
Hyperuricemia
Kidney
chemistry.chemical_compound
Rheumatology
Internal medicine
medicine
Humans
Genetic association
Genetics
biology
business.industry
nutritional and metabolic diseases
medicine.disease
Uric Acid
Endocrinology
chemistry
Renal physiology
biology.protein
Uric acid
Gene-Environment Interaction
business
Glycolysis
SLC2A9
Genome-Wide Association Study
Subjects
Details
- ISSN :
- 15583163
- Volume :
- 40
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Rheumatic diseases clinics of North America
- Accession number :
- edsair.doi.dedup.....d6109af4f29cd2deaea81fdd9f90f200