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What proportion of AQP4-IgG-negative NMO spectrum disorder patients are MOG-IgG positive? A cross sectional study of 132 patients
- Source :
- Journal of Neurology
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Antibodies to myelin oligodendrocyte glycoprotein (MOG-IgG) have been described in patients with neuromyelitis optica spectrum disorders (NMOSD) without aquaporin-4 antibodies (AQP4-IgG). We aimed to identify the proportion of AQP4-IgG-negative NMOSD patients who are seropositive for MOG-IgG. In a cross sectional study, we reviewed all patients seen in the National NMO clinic over the last 4 years (after the availability of MOG-IgG testing), including clinical information, MRI, and antibody tests. 261 unique patients were identified. 132 cases satisfied the 2015 NMOSD diagnostic criteria. Of these, 96 (73%) were AQP4-IgG positive and 36 (27%) were AQP4-IgG negative. These 36 patients were tested for MOG-IgG and 15/36 (42%) tested positive. 20% (25/125) of the patients who did not satisfy NMOSD criteria had MOG-IgG. Approximately half of seronegative NMOSD is MOG-Ig seropositive and one in five of non-NMOSD/non-MS demyelination is MOG-IgG positive. Since MOG-associated demyelinating disease is likely different from AQP4-IgG disease in terms of underlying disease mechanisms, relapse risk and possibly treatment, testing for MOG-IgG in patients with AQP4-IgG-negative NMOSD and other non-MS demyelination may have significant implications to management and clinical trials.
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
Neurology
Adolescent
Cross-sectional study
Disease
Myelin oligodendrocyte glycoprotein
Young Adult
03 medical and health sciences
0302 clinical medicine
Aquaporin-4 antibodies
immune system diseases
Internal medicine
Myelin oligodendrocytes glycoprotein
Demyelinating disease
medicine
Humans
Spectrum disorder
Aquaporin 4
Original Communication
Neuromyelitis optica
biology
business.industry
Neuromyelitis Optica
Middle Aged
medicine.disease
nervous system diseases
Clinical trial
Cross-Sectional Studies
030104 developmental biology
nervous system
Immunoglobulin G
Immunology
biology.protein
Female
Myelin-Oligodendrocyte Glycoprotein
sense organs
Neurology (clinical)
business
Immunosuppressive Agents
030217 neurology & neurosurgery
Demyelinating Diseases
Subjects
Details
- ISSN :
- 14321459 and 03405354
- Volume :
- 264
- Database :
- OpenAIRE
- Journal :
- Journal of Neurology
- Accession number :
- edsair.doi.dedup.....d638f2e89bf29c07f27a2904acc93512