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Clinical and biometrological efficacy of a hyaluronic acid-based mesotherapy product: a randomised controlled study
- Source :
- Archives of Dermatological Research
- Publisher :
- Springer Nature
-
Abstract
- Data demonstrating the efficacy of hyaluronic acid (HA)-based mesotherapy for skin rejuvenation are scarce. The aim of the study is to assess the efficacy of non-reticulated HA-based mesotherapy on skin elasticity and complexion radiance. 55 women with cutaneous ageing signs included in the Full Analysis Set (FAS) population blindly received intradermal micro-injections (50 × 0.02 mL) of non-cross-linked HA filler with mannitol (Glytone 1, HA concentration: 14 mg/g) in one cheek and saline physiological solution in the other according to hemifacial randomisation in 3 monthly sessions. Elasticity (E1 and E2 stiffness parameters) and dermis thickness were measured by cutometry and 20 MHz echography, before (D0) treatment and 1 (1M) and 3 months (3M) after the last injection. A trained panel blindly scored skin complexion radiance from standardised and calibrated photographs, using 100 mm analogue scales. In the FAS population, only HA filler significantly decreased E1 at 1M (−10.9 %, p = 0.026) and 3M (−10.5 %, p = 0.035) compared with D0; its effect versus the control tended to be more persistent, with a difference between treatments at 3M close to significance (p = 0.063). E2 also decreased at 1M (−8.2 %, p = 0.027 in the per protocol population, n = 53) and 3M after HA-treatment only. Dermis thickness significantly increased after HA-treatment at 1M (+3.4 %, p = 0.028) and 3M (+4 %, p = 0.008), and after control-treatment at 1M only (+2.5 %, p = 0.015). The HA filler significantly improved complexion radiance at 3M compared with the control (p = 0.012) and for 51 % of subjects, their skin status. Non-reticulated HA-based mesotherapy significantly and sustainably improves skin elasticity and complexion radiance.
- Subjects :
- Adult
medicine.medical_specialty
medicine.medical_treatment
Mesotherapy
Hyaluronic acid
Population
Urology
Cosmetic Techniques
Dermatology
law.invention
Dermis thickness
chemistry.chemical_compound
Dermis
Randomized controlled trial
law
Skin Physiological Phenomena
medicine
Humans
Regeneration
Rejuvenation
education
Saline
Aged
Skin
education.field_of_study
Original Paper
business.industry
General Medicine
Middle Aged
Skin Care
Elasticity
Micro-injection
Skin Aging
medicine.anatomical_structure
chemistry
Female
Mannitol
business
Skin elasticity
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 03403696
- Volume :
- 305
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Archives of Dermatological Research
- Accession number :
- edsair.doi.dedup.....d643de9f4dfdcf57aa60e261e5c164a2
- Full Text :
- https://doi.org/10.1007/s00403-013-1360-7