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Therapeutic strategies for severe COVID-19: a position paper from the Italian Society of Infectious and Tropical Diseases (SIMIT)
- Source :
- Clinical Microbiology and Infection
- Publication Year :
- 2021
-
Abstract
- Scope Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has become pandemic, reaching almost one million death worldwide. At present standard treatment for coronavirus disease 2019 (COVID-19) is not well defined because the evidence, either from randomized or observational studies, with conflicting results, has led to rapid changes in treatment guidelines. Our aim was to narratively summarize the available literature on the management of COVID-19 in order to combine current evidence and interpretation of the data by experts who are treating patients in the frontline setting. Methods The panel conducted a detailed review of the literature and eventual press releases from randomized clinical trials for each possible available treatment. Inductive PubMed search waws performed for publications relevant to the topic, including all clinical trials conducted. The result was a flowchart with treatment indications for patients with COVID-19. Implications After 6 months of a pandemic situation and before a possible second coronavirus wave descends on Europe, it is important to evaluate which drugs proved to be effective while also considering that results from many randomized clinical trials are still awaited. Indeed, among treatments for COVID-19, only glucocorticoids have resulted in an association with a significant decrease in mortality in published randomized controlled trials. New therapeutic strategies are urgently needed.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
030106 microbiology
Coronaviru
practice guidelines as topic
coronavirus
randomized controlled trials as topic
Guidelines
medicine.disease_cause
medical
law.invention
03 medical and health sciences
0302 clinical medicine
societies
Randomized controlled trial
law
Pandemic
italy
medicine
pneumonia
030212 general & internal medicine
Intensive care medicine
humans
Societies, Medical
Coronavirus
therapy
SARS-CoV-2
business.industry
COVID-19
Pneumonia
Therapy
Standard treatment
General Medicine
covid-19
sars-cov-2
societies, medical
standard of care
COVID-19 Drug Treatment
Clinical trial
Infectious Diseases
Position paper
Observational study
business
Human
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Clinical Microbiology and Infection
- Accession number :
- edsair.doi.dedup.....d650a7969d423b392e1b2b48de16b745