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Comparing Direct Stenting With Conventional Stenting in Patients With Acute Coronary Syndromes
- Source :
- Angiology. 67:317-325
- Publication Year :
- 2015
- Publisher :
- SAGE Publications, 2015.
-
Abstract
- Our aim was to compare direct stenting (DS) with conventional stenting (CS) in patients with acute coronary syndrome (ACS). We searched PubMed, EMBASE, and ISI web of science for eligible studies. Primary end point was major adverse cardiac events (MACEs) in short term. Secondary end points were 1-year mortality and after-procedural no-reflow phenomenon. Twelve trials in 8998 patients were included. The odds ratios (ORs) were pooled using the Mantel-Haenszel fixed effect model. Short-term MACEs were significantly reduced in the DS arm in contrast to the CS (5.00% vs 8.08%, DS vs CS, respectively, OR [95% confidence interval] = 0.61 [0.46-0.80], P = .0004). One-year mortality and after-procedural no-reflow phenomenon were significantly lower in the DS group. No heterogeneity was observed through I2 test ( Phet = .81, .89, and .77 for each end point, respectively). This meta-analysis demonstrated that in selected patients with ACS, DS is not only safe and feasible but also reduces short-term and 1-year mortality as well as the occurrence of after-procedural no-reflow phenomenon.
- Subjects :
- medicine.medical_specialty
Acute coronary syndrome
Time Factors
Myocardial Infarction
030204 cardiovascular system & hematology
Coronary Angiography
03 medical and health sciences
0302 clinical medicine
Internal medicine
Clinical endpoint
Humans
Medicine
Direct stenting
In patient
cardiovascular diseases
030212 general & internal medicine
Acute Coronary Syndrome
Angioplasty, Balloon, Coronary
Clinical Trials as Topic
business.industry
Odds ratio
medicine.disease
Confidence interval
Clinical trial
Treatment Outcome
Meta-analysis
Cardiology
Stents
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 19401574 and 00033197
- Volume :
- 67
- Database :
- OpenAIRE
- Journal :
- Angiology
- Accession number :
- edsair.doi.dedup.....d65b3eb2fec8e68c046a7221f07a2f32