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The prevalence of HPV infections in HPV-vaccinated women from the general population
- Source :
- APMIS. 125:585-595
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Currently, three prophylactic HPV vaccines are commercially available to prevent HPV 16/18 infection and associated lesions. The aim of the study was to assess markers of HPV infection in women/girls before vaccination and to ascertain the prevalence and spectrum of post-vaccination HPV types. Three hundred and thirty subjects of which 75 were virgins were enrolled. Before the first dose of the HPV vaccine and 1, 3 and 5 years after the completion of HPV vaccination, the samples for cytology, HPV detection and anti-HPV antibody response were taken. At enrolment, HPV DNA was detected in 38% of sexually active girls/women. At the first, second and third follow-up, HPV DNA was found in 40, 45, and 39% of them. The seroprevalence rates to HPV 6, 11, 16 and 18 in these subjects were 31, 21, 18 and 10%. On the follow-up significantly higher levels of antibodies to HPV 16/18 were found after application of divalent vaccine. Results of the study demonstrate high prevalence of HPV infection in young women. In a substantial number of women, HPV-specific antibodies as well as high-risk HPV types were detected. HPV-specific antibodies were also frequently found in non-sexually active girls. The acquisition of HPV after the onset of sexual life was very fast.
- Subjects :
- Adult
Microbiology (medical)
medicine.medical_specialty
Adolescent
Population
Cervix Uteri
HPV vaccines
Antibodies, Viral
Pathology and Forensic Medicine
Cohort Studies
Young Adult
03 medical and health sciences
0302 clinical medicine
Seroepidemiologic Studies
Internal medicine
medicine
Humans
Immunology and Allergy
Seroprevalence
Papillomavirus Vaccines
030212 general & internal medicine
education
Papillomaviridae
education.field_of_study
High prevalence
biology
Hpv types
business.industry
Papillomavirus Infections
HPV infection
virus diseases
General Medicine
Middle Aged
medicine.disease
Virology
female genital diseases and pregnancy complications
Vaccination
030220 oncology & carcinogenesis
DNA, Viral
biology.protein
Female
Antibody
business
Subjects
Details
- ISSN :
- 09034641
- Volume :
- 125
- Database :
- OpenAIRE
- Journal :
- APMIS
- Accession number :
- edsair.doi.dedup.....d667f6445e1cda45de7b14daf7b6e566