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A feasible CT feature to differentiate focal‐type autoimmune pancreatitis from pancreatic ductal adenocarcinoma
- Source :
- Cancer Medicine, Cancer Medicine, Vol 8, Iss 14, Pp 6250-6257 (2019)
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- Background To investigate whether the relative computed tomography (CT) value (rCT) of adjacent pancreatic parenchyma can distinguish focal‐type autoimmune pancreatitis (fAIP) from pancreatic ductal adenocarcinoma (PDAC). Methods A total of 13 patients with fAIP and 20 patients with PDAC were included in this study. The rCT was calculated as the ratio of the CT value of adjacent pancreatic parenchyma to that of muscle. The diagnostic performance of rCT for discriminating fAIP from PDAC was evaluated using receiver operating characteristic (ROC) analysis. Results Both fAIP and PDAC presented hyper‐fibrosis histologically and delayed enhancement on CT examination. Moreover, the pancreatic parenchyma of fAIP presented serious inflammation. The mean rCT of the parenchyma was significantly lower in fAIP than in PDAC in all phases. The best diagnostic performance of the rCT value was found in the pancreatic phase, with an area under the ROC curve of 0.912, while the areas under the ROC curve of the portal and delayed phases were 0.812 and 0.754, respectively. The optimal cut‐off value for distinguishing fAIP from PDAC was 1.62 in the pancreatic phase. Conclusions The rCT of the pancreatic parenchyma during the pancreatic phase may be a feasible CT feature for differentiating fAIP from PDAC.<br />Similar imaging features such as regional enlargement of the pancreas and delayed enhancement became a big challenge to differentiate focal‐type autoimmune pancreatitis (fAIP) from PDAC. In this study, we found that the pancreatic parenchyma of fAIP presented severe inflammation. Moreover, the mean relative computed tomography values of the pancreatic parenchyma were lower in fAIP than that in PDAC in all phases.
- Subjects :
- Adult
Male
0301 basic medicine
Pancreatic parenchyma
Cancer Research
medicine.medical_specialty
Pancreatic ductal adenocarcinoma
endocrine system diseases
Autoimmune Pancreatitis
pancreatic ductal adenocarcinoma
Computed tomography
lcsh:RC254-282
Diagnosis, Differential
03 medical and health sciences
0302 clinical medicine
Ct examination
Parenchyma
Biomarkers, Tumor
Image Processing, Computer-Assisted
medicine
Humans
Radiology, Nuclear Medicine and imaging
Original Research
Aged
Autoimmune pancreatitis
Receiver operating characteristic
medicine.diagnostic_test
business.industry
Clinical Cancer Research
computed tomography
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
digestive system diseases
Tumor Burden
Pancreatic Neoplasms
030104 developmental biology
ROC Curve
Oncology
Feature (computer vision)
030220 oncology & carcinogenesis
Female
Radiology
Tomography, X-Ray Computed
business
Carcinoma, Pancreatic Ductal
Subjects
Details
- ISSN :
- 20457634
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Cancer Medicine
- Accession number :
- edsair.doi.dedup.....d693b889a4d73523aa65e574a921008a