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Peptidorhamnomannan negatively modulates the immune response in a scedosporiosis murine model
- Source :
- Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
- Publication Year :
- 2016
-
Abstract
- In this study, we analyzed the impact of immunization with the peptidorhamnomannan (PRM) from the cell wall of the fungus Scedosporium (Lomentospora) prolificans in a murine model of invasive scedosporiosis. Immunization with PRM decreased the survival of mice infected with S. prolificans. Immunization of mice with PRM led to decreased secretion of pro-inflammatory cytokines and chemokines but did not affect the secretion of IL-10. Mice immunized with PRM showed an increase in IgG1 secretion, which is an immunoglobulin linked to a nonprotective response. Splenocytes isolated from mice infected with S. prolificans and immunized with PRM showed no differences in the percentages of Th17 cells and no increase in the frequency of the CD4(+)CD62L(Low) T cell population. PRM-immunized mice showed a significant increase in the percentage of Treg cells. In summary, our results indicated that immunization with PRM did not assist or improve the immunological response against S. prolificans infection. PRM exacerbated the infection process by reducing the inflammatory response, thereby facilitating colonization, virulence and dissemination by the fungus.
- Subjects :
- 0301 basic medicine
Chemokine
viruses
medicine.medical_treatment
T cell
030106 microbiology
Population
chemical and pharmacologic phenomena
T-Lymphocytes, Regulatory
03 medical and health sciences
Immune system
medicine
Animals
Scedosporium
education
Glycoproteins
education.field_of_study
Mice, Inbred BALB C
Scedosporium prolificans
biology
virus diseases
General Medicine
biochemical phenomena, metabolism, and nutrition
biology.organism_classification
humanities
Disease Models, Animal
030104 developmental biology
Infectious Diseases
Cytokine
medicine.anatomical_structure
Immunization
Mycoses
Immunoglobulin G
Immunology
biology.protein
Female
CAMUNDONGOS
Antibody
Fungal Vaccines
Immunosuppressive Agents
Subjects
Details
- ISSN :
- 14602709
- Volume :
- 54
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Medical mycology
- Accession number :
- edsair.doi.dedup.....d6a0f8f52a0613d2757cc11651c7eae0