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Amygdala hyperreactivity to faces conditioned with a social-evaluative meaning- a multiplex, multigenerational fMRI study on social anxiety endophenotypes
- Source :
- NeuroImage : Clinical, NeuroImage: Clinical, 26, 102247. ELSEVIER SCI LTD, NeuroImage: Clinical, NeuroImage: Clinical, Vol 26, Iss, Pp-(2020), NeuroImage: Clinical, 26. ELSEVIER SCI LTD
- Publication Year :
- 2019
-
Abstract
- Highlights • Leiden Family Lab study on Social Anxiety Disorder (SAD): focus on SAD endophenotypes. • fMRI: Amygdala reactivity to faces with a social-evaluative meaning (n = 105). • Amygdala hyperreactivity co-segregated with social anxiety within families. • Multiple voxels within these amygdala clusters were at least moderately heritable. • Amygdala response: neurobiological candidate endophenotype of social anxiety.<br />Social anxiety disorder (SAD) runs in families, but the neurobiological pathways underlying the genetic susceptibility towards SAD are largely unknown. Here, we employed an endophenotype approach, and tested the hypothesis that amygdala hyperreactivity to faces conditioned with a social-evaluative meaning is a candidate SAD endophenotype. We used data from the multiplex, multigenerational Leiden Family Lab study on Social Anxiety Disorder (eight families, n = 105) and investigated amygdala activation during a social-evaluative conditioning paradigm with high ecological validity in the context of SAD. Three neutral faces were repeatedly presented in combination with socially negative, positive or neutral sentences. We focused on two endophenotype criteria: co-segregation of the candidate endophenotype with the disorder within families, and heritability. Analyses of the fMRI data were restricted to the amygdala as a region of interest, and association analyses revealed that bilateral amygdala hyperreactivity in response to the conditioned faces co-segregated with social anxiety (SA; continuous measure) within the families; we found, however, no relationship between SA and brain activation in response to more specific fMRI contrasts. Furthermore, brain activation in a small subset of voxels within these amygdala clusters was at least moderately heritable. Taken together, these findings show that amygdala engagement in response to conditioned faces with a social-evaluative meaning qualifies as a neurobiological candidate endophenotype of social anxiety. Thereby, these data shed light on the genetic vulnerability to develop SAD.
- Subjects :
- Adult
Male
Ecological validity
Endophenotypes
Cognitive Neuroscience
Functional magnetic resonance imaging
Context (language use)
lcsh:Computer applications to medicine. Medical informatics
Amygdala
behavioral disciplines and activities
lcsh:RC346-429
050105 experimental psychology
03 medical and health sciences
0302 clinical medicine
mental disorders
medicine
Genetic predisposition
Humans
0501 psychology and cognitive sciences
Radiology, Nuclear Medicine and imaging
Genetic Predisposition to Disease
Association (psychology)
Social anxiety disorder
lcsh:Neurology. Diseases of the nervous system
medicine.diagnostic_test
05 social sciences
Social anxiety
Phobia, Social
Regular Article
Middle Aged
Magnetic Resonance Imaging
Pedigree
medicine.anatomical_structure
Neurology
nervous system
Endophenotype
lcsh:R858-859.7
Female
Neurology (clinical)
Psychology
Neuroscience
030217 neurology & neurosurgery
psychological phenomena and processes
Subjects
Details
- ISSN :
- 22131582
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- NeuroImage. Clinical
- Accession number :
- edsair.doi.dedup.....d6c62e4593df2a8bad071731f34177a1