Back to Search
Start Over
PEA3/ETV4-related transcription factors coupled with active ERK signalling are associated with poor prognosis in gastric adenocarcinoma
- Source :
- Keld, R, Guo, B, Downey, P, Cummins, R, Gulmann, C, Ang, Y S & Sharrocks, A D 2011, ' PEA3/ETV4-related transcription factors coupled with active ERK signalling are associated with poor prognosis in gastric adenocarcinoma ', British Journal of Cancer, vol. 105, no. 1, pp. 124-130 . https://doi.org/10.1038/bjc.2011.187, https://doi.org/10.1038/bjc.2011.187, British Journal of Cancer, Keld, R, Guo, B, Downey, P, Cummins, R, Gulmann, C, Ang, Y S & Sharrocks, A D 2011, ' PEA3/ETV4-related transcription factors coupled with active ERK signalling are associated with poor prognosis in gastric adenocarcinoma ' British Journal of Cancer, vol. 105, no. 1, pp. 124-130 . https://doi.org/10.1038/bjc.2011.187, https://doi.org/10.1038/bjc.2011.187
- Publication Year :
- 2011
-
Abstract
- Background:Transcription factors often play important roles in tumourigenesis. Members of the PEA3 subfamily of ETS-domain transcription factors fulfil such a role and have been associated with tumour metastasis in several different cancers. Moreover, the activity of the PEA3 subfamily transcription factors is potentiated by Ras-ERK pathway signalling, which is itself often deregulated in tumour cells.Methods:Immunohistochemical patterns of PEA3 expression and active ERK signalling were analysed and mRNA expression levels of PEA3, ER81, MMP-1 and MMP-7 were determined in gastric adenocarcinoma samples.Results:Here, we have studied the expression of the PEA3 subfamily members PEA3/ETV4 and ER81/ETV1 in gastric adenocarcinomas. PEA3 is upregulated at the protein level in gastric adenocarcinomas and both PEA3/ETV4 and ER81/ETV1 are upregulated at the mRNA level in gastric adenocarcinoma tissues. This increased expression correlates with the expression of a target gene associated with metastasis, MMP-1. Enhanced ERK signalling is also more prevalent in late-stage gastric adenocarcinomas, and the co-association of ERK signalling and PEA3 expression also occurs in late-stage gastric adenocarcinomas. Furthermore, the co-association of ERK signalling and PEA3 expression correlates with decreased survival rates.Conclusions:This study shows that members of the PEA3 subfamily of transcription factors are upregulated in gastric adenocarcinomas and that the simultaneous upregulation of PEA3 expression and ERK pathway signalling is indicative of late-stage disease and a poor survival prognosis. © 2011 Cancer Research UK All rights reserved.
- Subjects :
- MAPK/ERK pathway
Cancer Research
Adenocarcinoma
DNA-binding protein
Immunoenzyme Techniques
03 medical and health sciences
0302 clinical medicine
Stomach Neoplasms
Medicine
Humans
RNA, Messenger
Extracellular Signal-Regulated MAP Kinases
Transcription factor
Molecular Diagnostics
ER81
030304 developmental biology
0303 health sciences
ETV1
biology
Oncogene
business.industry
Reverse Transcriptase Polymerase Chain Reaction
ETV4
gastric cancer
PEA3
Cancer
medicine.disease
Prognosis
digestive system diseases
3. Good health
DNA-Binding Proteins
body regions
Oncology
Gastric Mucosa
030220 oncology & carcinogenesis
Mitogen-activated protein kinase
Case-Control Studies
Matrix Metalloproteinase 7
Cancer cell
Immunology
Cancer research
biology.protein
Matrix Metalloproteinase 1
business
MMP1
Transcription Factors
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Keld, R, Guo, B, Downey, P, Cummins, R, Gulmann, C, Ang, Y S & Sharrocks, A D 2011, ' PEA3/ETV4-related transcription factors coupled with active ERK signalling are associated with poor prognosis in gastric adenocarcinoma ', British Journal of Cancer, vol. 105, no. 1, pp. 124-130 . https://doi.org/10.1038/bjc.2011.187, https://doi.org/10.1038/bjc.2011.187, British Journal of Cancer, Keld, R, Guo, B, Downey, P, Cummins, R, Gulmann, C, Ang, Y S & Sharrocks, A D 2011, ' PEA3/ETV4-related transcription factors coupled with active ERK signalling are associated with poor prognosis in gastric adenocarcinoma ' British Journal of Cancer, vol. 105, no. 1, pp. 124-130 . https://doi.org/10.1038/bjc.2011.187, https://doi.org/10.1038/bjc.2011.187
- Accession number :
- edsair.doi.dedup.....d6d3d9ef4be1bdeecb7b40e88d665db2