Back to Search
Start Over
Synthesis and biological evaluation of the major metabolite of atomoxetine: elucidation of a partial κ-opioid agonist effect
- Source :
- Bioorganic & Medicinal Chemistry Letters. 14:4083-4085
- Publication Year :
- 2004
- Publisher :
- Elsevier BV, 2004.
-
Abstract
- The major human metabolite of atomoxetine (4-hydroxyatomoxetine) was tested against a panel of receptors and enzymes, and was found to interact with the mu, delta, and kappa-opioid receptors based upon studies involving both binding and functional assays. 4-hydroxyatomoxetine was determined to be a partial agonist of the kappa-opioid receptor.
- Subjects :
- medicine.drug_class
Metabolite
Clinical Biochemistry
Pharmaceutical Science
Pharmacology
Atomoxetine Hydrochloride
Biochemistry
Partial agonist
Structure-Activity Relationship
chemistry.chemical_compound
Opioid receptor
Drug Discovery
medicine
Humans
Receptor
Molecular Biology
Propylamines
Chemistry
Receptors, Opioid, kappa
Organic Chemistry
Atomoxetine
Biological activity
Opioid
Attention Deficit Disorder with Hyperactivity
Molecular Medicine
medicine.drug
Atomoxetine hydrochloride
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....d6e46da7e31a496e1ee4483b839289c9