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Quantifying the Onset of Unintended Weight Loss in Huntington’s Disease: A Retrospective Analysis of Enroll-HD
- Source :
- J Huntingtons Dis
- Publication Year :
- 2021
- Publisher :
- IOS Press, 2021.
-
Abstract
- Background: Unintended weight loss and decreased body mass indexes (BMIs) are common symptoms of individuals with manifest HD. It is unknown at what point during disease progression weight loss starts to accelerate relative to a healthy individual’s weight and when recommended interventions should be initiated to have the strongest impact on patient care. Objective: The objective of this study was to identify a point in time relative to age at motor onset when the decline in weight in HD starts to accelerate relative to a non-HD population. The relationship between initiation of weight loss interventions and changes in weight loss was also explored. Methods: Participants from the fifth version of the Enroll-HD study were identified for this research. Linear mixed-effects piecewise regression models were used to estimate the point in time relative to the reported age of motor onset in which BMI started to decline in participants with HD compared to healthy non-HD controls. A post-hoc descriptive analysis was performed to look at when nutritional supplements and swallow therapy were initiated in participants with HD relative to motor onset. Results: BMI decline in the HD group began to accelerate compared to controls approximately 5.7 years after the reported age of motor onset (95% CI: 4.7–6.9). The average initiation times of swallow therapy and nutritional supplements were 7.7 years (SD = 5.5 years) and 6.7 years (SD = 6.5 years) after motor onset, respectively. Conclusion: Our findings suggest a potential point for intervention of nutrition programs or therapies used to prevent future weight loss.
- Subjects :
- Pediatrics
medicine.medical_specialty
Population
Psychological intervention
Article
Patient care
Cellular and Molecular Neuroscience
Cognition
Huntington's disease
Weight loss
Weight Loss
medicine
Retrospective analysis
Humans
education
Retrospective Studies
education.field_of_study
business.industry
Disease progression
medicine.disease
Huntington Disease
Weight loss interventions
Disease Progression
Neurology (clinical)
medicine.symptom
business
Subjects
Details
- ISSN :
- 18796400 and 18796397
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Journal of Huntington's Disease
- Accession number :
- edsair.doi.dedup.....d6f6979a0b3ec4c9768c54160a83510e