Back to Search
Start Over
Relationships between ultrasound enthesitis, disease activity and axial radiographic structural changes in patients with early spondyloarthritis: data from DESIR cohort
- Source :
- RMD Open : Rheumatic & Musculoskeletal Diseases, RMD Open : Rheumatic & Musculoskeletal Diseases, 2017, 3 (2), pp.e000482. ⟨10.1136/rmdopen-2017-000482⟩, RMD Open, RMD Open : Rheumatic & Musculoskeletal Diseases, EULAR ; BMJ, 2017, 3 (2), pp.e000482. ⟨10.1136/rmdopen-2017-000482⟩
- Publication Year :
- 2017
- Publisher :
- BMJ, 2017.
-
Abstract
- Background To search for association between ultrasound (US) enthesis abnormalities and disease activity, spine and sacro-iliac joints (SIJ) MRI inflammatory lesions and spine structural changes in a cohort of patients suspected for axial spondyloarthritis (SpA). Methods Patients: Of 708 patients included in the DESIR(Devenir des Spondyloarthrites Indifferenciees Recentes) cohort, 402 had an US enthesis assessment and were selected for this study. Imaging: Achilles, lateral epicondyles, superior patellar ligament, inferior patellar ligament entheses were systematically US scanned and abnormalities were summed in US structural and power Doppler (PDUS) scores. Spine radiographs, SIJ and spine MRI scans were centrally scored modified Stoke Ankylosing Spondylitis Spine Score (mSASSS), presence of MRI sacro-iliitis, Spondyloarthritis Research Consortium of Canada and Berlin scores. Analysis: The associations between the US structural/PDUS scores and disease activity, C reactive protein (CRP), MRI SIJ and spine inflammatory lesions and mSASSS were tested by Spearman9s correlation tests. Results Among the 402 patients included (median age: 33.5 years, males: 48.5%), 55% had US enthesis structural abnormalities while 14% had PDUS abnormalities. There was no association between US scores and Bath Ankylosing Spondylitis Disease Activity Index, CRP or inflammatory lesions on SIJ and spine MRI. There was a correlation between US structural and PDUS scores and the mSASSS (respectively, r=0.151, p=0.005; r=0.143, p=0.007). The proportion of patients with syndesmophytes was higher in the case of US enthesophytes (26% of syndesmophytes vs 6% in the absence of US enthesophytes, p Conclusion While the US abnormalities do not seem to be a helpful tool for monitoring disease activity in axial SpA, US enthesophytes, strongly associated with axial syndesmophytes, might be a marker of interest for disease severity. Trial registration number NCT01648907, date of registration : 20 July 2012.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
[SDV]Life Sciences [q-bio]
Radiography
Immunology
03 medical and health sciences
0302 clinical medicine
Rheumatology
sacro-iliitis
Spondyloarthritis
Immunology and Allergy
Medicine
ComputingMilieux_MISCELLANEOUS
030203 arthritis & rheumatology
Ankylosing spondylitis
biology
ultrasound
business.industry
Patellar ligament
Ultrasound
C-reactive protein
Enthesitis
medicine.disease
Enthesis
Surgery
[SDV] Life Sciences [q-bio]
030104 developmental biology
medicine.anatomical_structure
Cohort
biology.protein
syndesmophytis
Radiology
medicine.symptom
business
Subjects
Details
- ISSN :
- 20565933
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- RMD Open
- Accession number :
- edsair.doi.dedup.....d703bc3fcbc1f01f17e3a62a5302e229