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Increased central memory T cells in patients with chronic pancreatitis
- Source :
- Pancreatology. 5:177-182
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- A dysregulated immune response has been suggested to be important for the pathogenesis of chronic pancreatitis (CP). Formation of immunological memory is based on the differentiation of naive T lymphocytes to memory T lymphocytes after exposure to antigens and specific cytokines. The aim of this study was to analyze peripheral blood mononuclear cells (PBMCs) in patients with CP for different T lymphocyte subsets including naive and memory T cells.PBMCs from 9 patients who had undergone pancreatic resection due to CP, 9 CP patients who had not been resected and 9 healthy controls were analyzed by flow cytometry.Patients with CP had a skewed distribution of T lymphocytes, with an increased level of CCR7+/CD45RA- central memory T lymphocytes compared to healthy controls. Nonresected CP patients and subjects who had undergone pancreatic resection due to CP had similar levels of central memory T lymphocytes.Our results indicate that the dysregulation of the immune system in chronic pancreatitis seems to persist even after removal of large parts of the local inflammatory site. We suggest that the increase of central memory T lymphocytes may be important for maintaining the inflammatory process in chronic pancreatitis.
- Subjects :
- Adult
CD4-Positive T-Lymphocytes
Male
Endocrinology, Diabetes and Metabolism
C-C chemokine receptor type 7
CD8-Positive T-Lymphocytes
Immunological memory
Pathogenesis
Immune system
T-Lymphocyte Subsets
medicine
Humans
In patient
Aged
Interleukin-15
Hepatology
biology
business.industry
C-reactive protein
Gastroenterology
Middle Aged
biochemical phenomena, metabolism, and nutrition
medicine.disease
C-Reactive Protein
Immune System Diseases
Pancreatitis
Interleukin 15
Chronic Disease
Immunology
biology.protein
Female
business
Immunologic Memory
Subjects
Details
- ISSN :
- 14243903
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Pancreatology
- Accession number :
- edsair.doi.dedup.....d70cb0d9289eef844ccb4a155931c6c1