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T-cell repertoire diversity and clonal expansions in normal and clinical samples

Authors :
Jos Even
Christophe Pannetier
Philippe Kourilsky
Source :
Immunology Today. 16:176-181
Publication Year :
1995
Publisher :
Elsevier BV, 1995.

Abstract

Improved polymerase chain reaction (PCR)-based methods now permit a more in-depth analysis of the repertoire of T cells recovered in biological samples from mice and humans. At a certain level of resolution, the diversity of the T-cell repertoire can be readily estimated and clonal expansions become easily detectable. As discussed here by Christophe Pannetier, Jos Even and Philippe Kourilsky, these improvements allow a better appreciation of the degree of reproducibility of immune responses, both in mice and humans, and should have a significant impact on clinical investigations.

Details

ISSN :
01675699
Volume :
16
Database :
OpenAIRE
Journal :
Immunology Today
Accession number :
edsair.doi.dedup.....d714da43a1a0194e37af350ba492d6c6
Full Text :
https://doi.org/10.1016/0167-5699(95)80117-0