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Evaluation of genes associated with human myxomatous mitral valve disease in dogs with familial myxomatous mitral valve degeneration
- Source :
- The Veterinary Journal. 232:16-19
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Myxomatous mitral valve disease (MMVD) is the most common heart disease in the dog. It is believed to be heritable in Cavalier King Charles spaniels (CKCS) and Dachshunds. Myxomatous mitral valve disease is a familial disease in human beings as well and genetic mutations have been associated with its development. We hypothesized that a genetic mutation associated with the development of the human form of MMVD was associated with the development of canine MMVD. DNA was isolated from blood samples from 10 CKCS and 10 Dachshunds diagnosed with MMVD, and whole genome sequences from each animal were obtained. Variant calling from whole genome sequencing data was performed using a standardized bioinformatics pipeline for all samples. After filtering, the canine genes orthologous to the human genes known to be associated with MMVD were identified and variants were assessed for likely pathogenic implications. No variant was found in any of the genes evaluated that was present in least eight of 10 affected CKCS or Dachshunds. Although mitral valve disease in the CKCS and Dachshund is a familial disease, we did not identify genetic cause in the genes responsible for the human disease in the dogs studied here.
- Subjects :
- 0301 basic medicine
Pathology
medicine.medical_specialty
Heart disease
Dachshund
Heart Valve Diseases
Disease
03 medical and health sciences
Myxomatous mitral valve degeneration
Dogs
Species Specificity
Mitral valve
Animals
Humans
Medicine
Dog Diseases
Gene
Whole genome sequencing
Mitral Valve Prolapse
Whole Genome Sequencing
General Veterinary
business.industry
DNA
medicine.disease
030104 developmental biology
medicine.anatomical_structure
Mutation
Mitral Valve
Animal Science and Zoology
Human genome
business
Subjects
Details
- ISSN :
- 10900233
- Volume :
- 232
- Database :
- OpenAIRE
- Journal :
- The Veterinary Journal
- Accession number :
- edsair.doi.dedup.....d722671f7b14a9b974417c1e0138991e
- Full Text :
- https://doi.org/10.1016/j.tvjl.2017.12.002