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Sodium-glucose co-transporter-2 inhibitors for the prevention of cardiorenal outcomes in type 2 diabetes: An updated meta-analysis
- Publication Year :
- 2021
-
Abstract
- A meta-analysis of cardiorenal outcomes of sodium-glucose co-transporter-2 inhibitors (SGLT-2is) available in Europe or the United States in patients with type 2 diabetes (T2D) is presented. An electronic search up to 6 January 2021 was conducted to determine eligible trials. A total of eight cardiorenal outcomes trials of SGLT-2is (empagliflozin, canagliflozin, dapagliflozin, ertugliflozin and sotagliflozin) were identified, with 65,587 patients. Data were analysed using a random effects model. Overall, SGLT-2is were associated with a 12% reduced risk of major adverse cardiovascular events (MACE; HR = 0.88; 95% CI, 0.83-0.93; Q statistic, p = .19), with no significant heterogeneity (p for interaction = .465) between subgroups of patients with or without cardiovascular disease (CVD). The risk of the composite renal outcome was significantly reduced by treatment with SGLT-2is (HR = 0.61, 95% CI, 0.54-0.70), with no significant heterogeneity of associations with outcome (I2 = 37%, p = .11), and no difference in the risk between patients with or without CVD (p for interaction = .665). SGLT-2is have moderate benefits on MACE and major benefits on the progression of diabetic kidney disease.
- Subjects :
- medicine.medical_specialty
ertugliflozin
Endocrinology, Diabetes and Metabolism
empagliflozin
030209 endocrinology & metabolism
Disease
Type 2 diabetes
030204 cardiovascular system & hematology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Internal medicine
Internal Medicine
Empagliflozin
Medicine
Humans
Hypoglycemic Agents
Dapagliflozin
canagliflozin
Sodium-Glucose Transporter 2 Inhibitors
Canagliflozin
type 2 diabete
Hypoglycemic Agent
Symporters
business.industry
Sodium-Glucose Transporter 2 Inhibitor
Sodium
sotagliflozin
dapagliflozin
Random effects model
medicine.disease
Europe
cardiorenal outcome
Glucose
chemistry
Diabetes Mellitus, Type 2
Meta-analysis
business
Mace
medicine.drug
Human
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....d7268bf3fd32732835fb9cbb610936a9