Photoluminescence and in vitro cytotoxicity analysis in a novel mononuclear Zn(II) coordination compound based on bumetanide

A novel coordination compound based on Zn(II) and bumetanide (Hbum) of general formulae [Zn(bum)(HO)]·2HO has been synthesized and fully characterized by elemental analyses and single crystal X-ray diffraction. The results indicate that compound 1 possesses a monomeric structure in which the main intermolecular interactions stabilizing the structure are hydrogen bonds. Due to the fully filled d orbitals of Zn(II), this coordination compound could be an ideal candidate to show strong emission. That is the reason why, photoluminescence properties have been studied showing that this compound presents ligand derived emission ruled by ligand-centred π-π* electronic transitions. Additionally, because of the well-recognised therapeutic properties of bumetanide, antiparasitic efficacy against three leishmania spp. strains has been studied for the corresponding ligand and coordination compound.
This work has been funded by Junta de Andalucía (FQM-394), the Spanish Ministry of Economy and Competitiveness (MCIU/AEI/FEDER, UE) (PGC2018-102052-A-C22, PGC2018-102052-B-C21 and PGC2018-102047-B-I00), Red Guipuzcoana de Ciencia, Tecnología e Innovación (OF188/2017), University of the Basque Country (GIU 17/13). E.E. is grateful to the Government of the Basque Country for the predoctoral fellowship. The authors thank for technical and human support provided by SGIker of UPV/EHU and European funding (ERDF and ESF).