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Netrins Promote Developmental and Therapeutic Angiogenesis
- Source :
- Science. 313:640-644
- Publication Year :
- 2006
- Publisher :
- American Association for the Advancement of Science (AAAS), 2006.
-
Abstract
- Axonal guidance and vascular patterning share several guidance cues, including proteins in the netrin family. We demonstrate that netrins stimulate proliferation, migration, and tube formation of human endothelial cells in vitro and that this stimulation is independent of known netrin receptors. Suppression of netrin1a messenger RNA in zebrafish inhibits vascular sprouting, implying a proangiogenic role for netrins during vertebrate development. We also show that netrins accelerate neovascularization in an in vivo model of ischemia and that they reverse neuropathy and vasculopathy in a diabetic murine model. We propose that the attractive vascular and neural guidance functions of netrins offer a unique therapeutic potential.
- Subjects :
- Vascular Endothelial Growth Factor A
DNA, Complementary
Embryo, Nonmammalian
animal structures
Angiogenesis
Neural Conduction
Neovascularization, Physiologic
Receptors, Cell Surface
Article
Cell Line
Neovascularization
Mice
Diabetic Neuropathies
Cell Movement
Ischemia
Netrin
medicine
Animals
Humans
Nerve Growth Factors
Therapeutic angiogenesis
Muscle, Skeletal
Zebrafish
Tube formation
Multidisciplinary
biology
Chemotaxis
Tumor Suppressor Proteins
fungi
Endothelial Cells
Genetic Therapy
Netrin-1
biology.organism_classification
Cell biology
Vascular endothelial growth factor A
nervous system
embryonic structures
Immunology
Angiogenesis Inducing Agents
Netrins
Endothelium, Vascular
medicine.symptom
Netrin Receptors
Diabetic Angiopathies
Subjects
Details
- ISSN :
- 10959203 and 00368075
- Volume :
- 313
- Database :
- OpenAIRE
- Journal :
- Science
- Accession number :
- edsair.doi.dedup.....d73e989205a0210146aa2e9c32ba9822