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The hydrazide/hydrazone click reaction as a biomolecule labeling strategy for M(CO)3 (M = Re, (99m)Tc) radiopharmaceuticals
- Source :
- Chemical communications (Cambridge, England). 47(48)
- Publication Year :
- 2011
-
Abstract
- Facile reactivity of hydrazides and aldehydes was explored as potential coupling partners for incorporation into M(CO)(3) (M = Re, (99m)Tc) based radiopharmaceuticals. Both 'click, then chelate' and 'prelabel, then click' synthetic routes produced identical products in high yields and lacked metal-hydrazide/-hydrazone interactions, highlighting the potential of this click strategy.
- Subjects :
- Hydrazone
Hydrazide
Catalysis
Article
chemistry.chemical_compound
Coordination Complexes
Materials Chemistry
Reactivity (chemistry)
Chelation
chemistry.chemical_classification
Extramural
Biomolecule
Metals and Alloys
Hydrazones
Technetium
General Chemistry
Combinatorial chemistry
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Hydrazines
Rhenium
chemistry
Metals
Ceramics and Composites
Click chemistry
Click Chemistry
Radiopharmaceuticals
Subjects
Details
- ISSN :
- 1364548X
- Volume :
- 47
- Issue :
- 48
- Database :
- OpenAIRE
- Journal :
- Chemical communications (Cambridge, England)
- Accession number :
- edsair.doi.dedup.....d740024f16c82c204a771ae23418c451