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The hydrazide/hydrazone click reaction as a biomolecule labeling strategy for M(CO)3 (M = Re, (99m)Tc) radiopharmaceuticals

Authors :
Dejan-Krešimir Bučar
Benjamin B. Kasten
Clifford E. Berkman
Leonard R. MacGillivray
Paul D. Benny
Tanushree Ganguly
Source :
Chemical communications (Cambridge, England). 47(48)
Publication Year :
2011

Abstract

Facile reactivity of hydrazides and aldehydes was explored as potential coupling partners for incorporation into M(CO)(3) (M = Re, (99m)Tc) based radiopharmaceuticals. Both 'click, then chelate' and 'prelabel, then click' synthetic routes produced identical products in high yields and lacked metal-hydrazide/-hydrazone interactions, highlighting the potential of this click strategy.

Details

ISSN :
1364548X
Volume :
47
Issue :
48
Database :
OpenAIRE
Journal :
Chemical communications (Cambridge, England)
Accession number :
edsair.doi.dedup.....d740024f16c82c204a771ae23418c451