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Polymorphisms of methylenetetrahydrofolate reductase and methionine synthase genes and bladder cancer risk: a case-control study with meta-analysis
- Source :
- Clinical and experimental medicine. 9(1)
- Publication Year :
- 2008
-
Abstract
- Folate deficiency due to the methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS) variants leads to carcinogenesis by affecting DNA synthesis, repair, and methylation. We hypothesized that the MTHFR C677T, A1298C, and MS A2756G polymorphisms are associated with risk of bladder cancer. In a case–control study of 239 bladder cancer cases and 250 cancer-free controls, we found that the MTHFR 677TT genotype was statistically significantly associated with an increased risk of bladder cancer compared with the 677CC genotype (OR = 2.06, 95% CI = 1.16–3.64). Furthermore, the TA haplotype was associated with a significantly increased bladder cancer risk (OR = 1.38, 95% CI = 1.05–1.81) than was the most common haplotype, CA (e.g., CA denotes MTHFR 677C -1298A). We also found that the combined genotypes with 4–6 variant (risk) alleles (i.e., MTHFR 677T, 1298A, and MS 2756G alleles) were associated with an increased risk of bladder cancer (OR = 1.62, 95% CI = 1.03–2.53) compared with those with 0–3 variants, and this increased risk was more pronounced among subgroup of older people (OR = 1.71, 95% CI = 1.03–2.83). A meta-analysis of seven studies did not show a significant risk of bladder cancer in the MTHFR polymorphisms. The MTHFR polymorphisms and their haplotypes appear to jointly contribute to risk of bladder cancer.
- Subjects :
- Male
Risk
medicine.medical_specialty
Genotype
Biology
medicine.disease_cause
Gastroenterology
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Polymorphism, Single Nucleotide
General Biochemistry, Genetics and Molecular Biology
Linkage Disequilibrium
Gene Frequency
Internal medicine
medicine
Humans
Methionine synthase
Allele
Methylenetetrahydrofolate Reductase (NADPH2)
Aged
Genetics
Bladder cancer
Haplotype
Case-control study
General Medicine
Middle Aged
medicine.disease
digestive system diseases
Urinary Bladder Neoplasms
Methylenetetrahydrofolate reductase
Case-Control Studies
biology.protein
Female
Carcinogenesis
Subjects
Details
- ISSN :
- 15918890
- Volume :
- 9
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Clinical and experimental medicine
- Accession number :
- edsair.doi.dedup.....d743e7d69cee12ff1748a4b11b9e4a7f