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The Dialogue of the Host-Parasite Relationship: Leishmania spp. and Trypanosoma cruzi Infection
- Source :
- BioMed Research International, Vol 2015 (2015), BioMed Research International
- Publication Year :
- 2015
- Publisher :
- Hindawi Limited, 2015.
-
Abstract
- The intracellular protozoaLeishmaniaspp. andTrypanosoma cruziand the causative agents of Leishmaniasis and Chagas disease, respectively, belong to the Trypanosomatidae family. Together, these two neglected tropical diseases affect approximately 25 million people worldwide. Whether the host can control the infection or develops disease depends on the complex interaction between parasite and host. Parasite surface and secreted molecules are involved in triggering specific signaling pathways essential for parasite entry and intracellular survival. The recognition of the parasite antigens by host immune cells generates a specific immune response.Leishmaniaspp. andT. cruzihave a multifaceted repertoire of strategies to evade or subvert the immune system by interfering with a range of signal transduction pathways in host cells, which causes the inhibition of the protective response and contributes to their persistence in the host. The current therapeutic strategies in leishmaniasis and trypanosomiasis are very limited. Efficacy is variable, toxicity is high, and the emergence of resistance is increasingly common. In this review, we discuss the molecular basis of the host-parasite interaction ofLeishmaniaandTrypanosoma cruziinfection and their mechanisms of subverting the immune response and how this knowledge can be used as a tool for the development of new drugs.
- Subjects :
- Chagas disease
Trypanosoma cruzi
lcsh:Medicine
Review Article
Biology
General Biochemistry, Genetics and Molecular Biology
Host-Parasite Interactions
Immune system
Antigen
parasitic diseases
medicine
Humans
Chagas Disease
Antigens
Leishmaniasis
Leishmania
General Immunology and Microbiology
lcsh:R
General Medicine
Acquired immune system
medicine.disease
biology.organism_classification
Virology
Trypanosomiasis
Subjects
Details
- Language :
- English
- ISSN :
- 23146141 and 23146133
- Volume :
- 2015
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....d772dbd73f23c5778c8e11dd45b6f84d