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In-vitro activity of solithromycin against anaerobic bacteria from the normal intestinal microbiota
- Source :
- Anaerobe. 42
- Publication Year :
- 2016
-
Abstract
- Solithromycin is a novel fluoroketolide with high activity against bacteria associated with community-acquired respiratory tract infections as well as gonorrhea. However, data on the activity of solithromycin against anaerobic bacteria from the normal intestinal microbiota are scarce. In this study, 1024 Gram-positive and Gram-negative anaerobic isolates from the normal intestinal microbiota were analyzed for in-vitro susceptibility against solithromycin and compared to azithromycin, amoxicillin/clavulanic acid, ceftriaxone, metronidazole and levofloxacin by determining the minimum inhibitory concentration (MIC). Solithromycin was active against Bifidobacteria (MIC50, 0.008 mg/L) and Lactobacilli (MIC50, 0.008 mg/L). The MIC50 for Clostridia, Bacteroides, Prevotella and Veillonella were 0.5, 0.5, 0.125 and 0.016 mg/L, respectively. Gram-positive anaerobes were more susceptible to solithromycin as compared to the other antimicrobials tested. The activity of solithromycin against Gram-negative anaerobes was equal or higher as compared to other tested agents.
- Subjects :
- 0301 basic medicine
Solithromycin
030106 microbiology
Veillonella
Levofloxacin
Microbial Sensitivity Tests
Azithromycin
Amoxicillin-Potassium Clavulanate Combination
Gram-Positive Bacteria
Microbiology
03 medical and health sciences
Minimum inhibitory concentration
Bacteria, Anaerobic
Species Specificity
Clavulanic acid
Metronidazole
medicine
Prevotella
Humans
Anaerobiosis
Gram-Negative Anaerobic Bacteria
biology
Ceftriaxone
Amoxicillin
Triazoles
biology.organism_classification
Anti-Bacterial Agents
Gastrointestinal Microbiome
Gastrointestinal Tract
Infectious Diseases
Anaerobic bacteria
Macrolides
Bacteroides
medicine.drug
Subjects
Details
- ISSN :
- 10958274
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- Anaerobe
- Accession number :
- edsair.doi.dedup.....d78605a94d050e382b4f572f2ac446e7