Back to Search
Start Over
Efficacy of preoperative chemoradiotherapy in downstaging rectal cancer and its impact on the long-term outcome
- Source :
- South Asian Journal of Cancer, South Asian Journal of Cancer, Vol 8, Iss 2, Pp 98-101 (2019)
- Publication Year :
- 2019
- Publisher :
- Wolters Kluwer - Medknow, 2019.
-
Abstract
- Introduction: Response to preoperative chemoradiation (PRTCT) for rectal cancer predicts the long-term outcome. Context: Tertiary care hospital. Aims: The aim is to study the factors affecting the response to chemoradiation. Settings and Design: Retrospective. Materials and Methods: Twenty-three patients of rectal cancer undergoing PRTCT followed by surgery and adjuvant chemotherapy were followed up for 20–56 months. Postoperative response, tumor downstaging and nodal downstaging were correlated with the disease status. Results: Tumor downstaging was seen in 11 (50%) and nodal downstaging in 12 (63.15%) patients. Nodal downstaging was statistically significant with P = 0.004. Pathological complete response (PCR) was seen in one patient and partial response (PR) in 17 patients. Thirteen (72.2% of patients) were alive and disease free and the negative nodal status correlated with long-term control with P = 0.04. Conclusion: Most patients of rectal cancer show PR to PRTCT, and the benefit is more for node-positive patients. Nodal PCR is associated with a higher chance of long-term disease control.
- Subjects :
- long-term outcome
Cancer Research
medicine.medical_specialty
Disease status
Colorectal cancer
Adjuvant chemotherapy
preoperative radiation
Context (language use)
Gastroenterology
lcsh:RC254-282
03 medical and health sciences
0302 clinical medicine
Downstaging
Internal medicine
Nodal status
Medicine
rectal cancer
Pathological
Complete response
0303 health sciences
Preoperative chemoradiotherapy
030306 microbiology
business.industry
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Oncology
030220 oncology & carcinogenesis
business
ORIGINAL ARTICLE: GI Cancers
Subjects
Details
- Language :
- English
- ISSN :
- 22784306 and 2278330X
- Volume :
- 8
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- South Asian Journal of Cancer
- Accession number :
- edsair.doi.dedup.....d79e3ca5194feec3f5a7154822901871