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Impaired fasting blood glucose is associated to cognitive impairment and cerebral atrophy in middle-aged non-human primates
- Source :
- Aging (Albany NY), Aging, Aging, 2016, 9, pp.173-186. ⟨10.18632/aging.101148⟩, Aging, Superintendent of Documents, U.S. Government Printing Office, 2016, 9, pp.173-186. ⟨10.18632/aging.101148⟩, Aging, Impact Journals, 2016, 9, pp.173-186. ⟨10.18632/aging.101148⟩
- Publication Year :
- 2016
- Publisher :
- Impact Journals LLC, 2016.
-
Abstract
- International audience; Age-associated cognitive impairment is a major health and social issue because of increasing aged population. Cognitive decline is not homogeneous in humans and the determinants leading to differences between subjects are not fully understood. In middle-aged healthy humans, fasting blood glucose levels in the upper normal range are associated with memory impairment and cerebral atrophy. Due to a close evolutional similarity to Man, non-human primates may be useful to investigate the relationships between glucose homeostasis, cognitive deficits and structural brain alterations. In the grey mouse lemur, $Microcebus\ murinus$, spatial memory deficits have been associated with age and cerebral atrophy but the origin of these alterations have not been clearly identified. Herein, we showed that, on 28 female grey mouse lemurs (age range 2.4-6.1 years-old), age correlated with impaired fasting blood glucose (r$_s$=0.37) but not with impaired glucose tolerance or insulin resistance. In middle-aged animals (4.1-6.1 years-old), fasting blood glucose was inversely and closely linked with spatial memory performance (r$_s$=0.56) and hippocampus (r$_s$=-0.62) or septum (r$_s$=-0.55) volumes. These findings corroborate observations in humans and further support the grey mouse lemur as a natural model to unravel mechanisms which link impaired glucose homeostasis, brain atrophy and cognitive processes.
- Subjects :
- 0301 basic medicine
Blood Glucose
Aging
medicine.medical_specialty
Microcebus murinus
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Impaired glucose tolerance
03 medical and health sciences
0302 clinical medicine
Insulin resistance
Atrophy
Internal medicine
medicine
Glucose homeostasis
Animals
Cognitive Dysfunction
Cognitive decline
middle age
hippocampal/septal atrophy
Spatial Memory
Cerebral atrophy
Cerebral Cortex
biology
Mouse lemur
Age Factors
Cell Biology
Fasting
Organ Size
biology.organism_classification
medicine.disease
spontaneous models
030104 developmental biology
Endocrinology
spatial memory performance
Female
Psychology
Cheirogaleidae
Neuroscience
030217 neurology & neurosurgery
Research Paper
Subjects
Details
- Language :
- English
- ISSN :
- 19454589 and 00020966
- Volume :
- 9
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Aging (Albany NY)
- Accession number :
- edsair.doi.dedup.....d7dc4e4cd5c96dac6049c5f08c8dd62f