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Optimal donor for African Americans with hematologic malignancy: HLA-haploidentical relative or umbilical cord blood transplant
- Source :
- Biol Blood Marrow Transplant, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, vol 26, iss 10, Biology of Blood and Marrow Transplantation, 26(10), 1930-1936. Elsevier Science
- Publication Year :
- 2020
-
Abstract
- Although hematopoietic cell transplantation from an HLA-matched unrelated donor is potentially curative for hematologic malignancies, survival is lower for African Americans compared with Caucasians. Because only approximately 20% of African Americans will have an HLA-matched unrelated donor, many of these patients undergo HLA-haploidentical relative or umbilical cord blood transplantation. In this study, we analyzed outcomes after HLA-haploidentical related donor (n = 249) and umbilical cord blood (n = 118) transplantations in African American patients with hematologic malignancy between 2008 and 2016. The predominant disease was acute myelogenous leukemia for recipients of both types of donor grafts. The incidences of grade II-IV and III-IV acute graft-versus-host disease were higher after umbilical cord blood transplantation compared with HLA-haploidentical relative transplantation (56% and 29%, respectively, versus 33% and 11%, respectively; P
- Subjects :
- Transplantation Conditioning
IMPACT
Stem Cell Research - Umbilical Cord Blood/ Placenta - Human
GVHD
Graft vs Host Disease
Disease
Regenerative Medicine
Gastroenterology
Umbilical cord
Alternative donor
0302 clinical medicine
Stem Cell Research - Nonembryonic - Human
CYCLOPHOSPHAMIDE
African American
race
Cancer
Histocompatibility Testing
leukemia
Hematopoietic Stem Cell Transplantation
Transplant-Related Mortality
Hematology
Fetal Blood
Tissue Donors
Leukemia
medicine.anatomical_structure
030220 oncology & carcinogenesis
Hematologic Neoplasms
SURVIVAL
Cord Blood Stem Cell Transplantation
ACCESS
Stem Cell Research - Umbilical Cord Blood/ Placenta
medicine.medical_specialty
Clinical Sciences
Immunology
transplant-related mortality
Human leukocyte antigen
Caucasian
Article
HEMATOPOIETIC-CELL TRANSPLANTATION
03 medical and health sciences
Myelogenous
Rare Diseases
Clinical Research
Internal medicine
medicine
Humans
ACUTE-LEUKEMIA
Transplantation
Umbilical Cord Blood Transplantation
business.industry
GRAFT
NEED
ADULTS
medicine.disease
Stem Cell Research
Black or African American
Good Health and Well Being
business
030215 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 10838791
- Database :
- OpenAIRE
- Journal :
- Biol Blood Marrow Transplant, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, vol 26, iss 10, Biology of Blood and Marrow Transplantation, 26(10), 1930-1936. Elsevier Science
- Accession number :
- edsair.doi.dedup.....d7f765ed34a096b57730e9ef295b24ce