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Genome-wide haplotype association study identify TNFRSF1A, CASP7, LRP1B, CDH1 and TG genes associated with Alzheimer's disease in Caribbean Hispanic individuals
- Source :
- Oncotarget
- Publication Year :
- 2015
- Publisher :
- Impact Journals, LLC, 2015.
-
Abstract
- Alzheimer's disease (AD) is an acquired disorder of cognitive and behavioral impairment. It is considered to be caused by variety of factors, such as age, environment and genetic factors. In order to identify the genetic affect factors of AD, we carried out a bioinformatic approach which combined genome-wide haplotype-based association study with gene prioritization. The raw SNP genotypes data was downloaded from GEO database (GSE33528). It contains 615 AD patients and 560 controls of Caribbean Hispanic individuals. Firstly, we identified the linkage disequilibrium (LD) haplotype blocks and performed genome-wide haplotype association study to screen significant haplotypes that were associated with AD. Then we mapped these significant haplotypes to genes and obtained candidate genes set for AD. At last, we prioritized AD candidate genes based on their similarity with 36 known AD genes, so as to identify AD related genes. The results showed that 141 haplotypes on 134 LD blocks were significantly associated with AD (P
- Subjects :
- Candidate gene
Linkage disequilibrium
Muscle Proteins
Genome-wide association study
Biology
Polymorphism, Single Nucleotide
Genome
Linkage Disequilibrium
Alzheimer Disease
Antigens, CD
Pathology Section
Genotype
Humans
SNP
Genetic Predisposition to Disease
Genetic association
Caspase 7
Genetics
haplotype association analysis
Microfilament Proteins
Haplotype
Hispanic or Latino
Alzheimer's disease
Cadherins
Research Paper: Pathology
Caribbean Region
Haplotypes
Receptors, LDL
Oncology
Receptors, Tumor Necrosis Factor, Type I
Genome-Wide Association Study
Subjects
Details
- ISSN :
- 19492553
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Oncotarget
- Accession number :
- edsair.doi.dedup.....d801764a676103f0ac6a319c011ebe31
- Full Text :
- https://doi.org/10.18632/oncotarget.6391