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Genome-wide haplotype association study identify TNFRSF1A, CASP7, LRP1B, CDH1 and TG genes associated with Alzheimer's disease in Caribbean Hispanic individuals

Authors :
Zhang Rui-jie
Jin Li
Lian Duan
Zhenwei Shang
Hongchao Lv
Guiyou Liu
Situo Wang
Mingming Zhang
Yongshuai Jiang
Source :
Oncotarget
Publication Year :
2015
Publisher :
Impact Journals, LLC, 2015.

Abstract

Alzheimer's disease (AD) is an acquired disorder of cognitive and behavioral impairment. It is considered to be caused by variety of factors, such as age, environment and genetic factors. In order to identify the genetic affect factors of AD, we carried out a bioinformatic approach which combined genome-wide haplotype-based association study with gene prioritization. The raw SNP genotypes data was downloaded from GEO database (GSE33528). It contains 615 AD patients and 560 controls of Caribbean Hispanic individuals. Firstly, we identified the linkage disequilibrium (LD) haplotype blocks and performed genome-wide haplotype association study to screen significant haplotypes that were associated with AD. Then we mapped these significant haplotypes to genes and obtained candidate genes set for AD. At last, we prioritized AD candidate genes based on their similarity with 36 known AD genes, so as to identify AD related genes. The results showed that 141 haplotypes on 134 LD blocks were significantly associated with AD (P

Details

ISSN :
19492553
Volume :
6
Database :
OpenAIRE
Journal :
Oncotarget
Accession number :
edsair.doi.dedup.....d801764a676103f0ac6a319c011ebe31
Full Text :
https://doi.org/10.18632/oncotarget.6391