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Long-term impairment of neurovascular coupling following experimental subarachnoid hemorrhage
- Source :
- J Cereb Blood Flow Metab
- Publication Year :
- 2019
- Publisher :
- SAGE Publications, 2019.
-
Abstract
- CO2-reactivity and neurovascular coupling are sequentially lost within the first 24 h after subarachnoid hemorrhage (SAH). Whether and when these impairments recover is not known. Therefore, we investigated the reactivity of pial and intraparenchymal vessels by in vivo two-photon microscopy one month after experimental SAH. C57BL/6 mice were subjected to either sham surgery or SAH by filament perforation. One month later, cerebral blood flow following CO2-challenge and forepaw stimulation was assessed by laser Doppler fluxmetry. Diameters of pial and intraparenchymal arterioles were quantified by in vivo two-photon microscopy. One month after SAH, pial and parenchymal vessels dilated in response to CO2. Neurovascular coupling was almost completely absent after SAH: vessel diameter did not change upon forepaw stimulation compared to a 20% increase in sham-operated mice. The current results demonstrate that neurovascular function differentially recovers after SAH: while CO2-reactivity normalizes within one month after SAH, neurovascular coupling is still absent. These findings show an acute and persistent loss of neurovascular coupling after SAH that may serve as a link between early brain injury and delayed cerebral ischemia, two distinct pathophysiological phenomena after SAH that were so far believed not to be directly related.
- Subjects :
- medicine.medical_specialty
Subarachnoid hemorrhage
Perforation (oil well)
Ischemia
Mice
03 medical and health sciences
0302 clinical medicine
In vivo
Internal medicine
medicine
Animals
cardiovascular diseases
030304 developmental biology
0303 health sciences
business.industry
Sham surgery
Original Articles
Subarachnoid Hemorrhage
medicine.disease
Neurovascular bundle
Pathophysiology
nervous system diseases
Mice, Inbred C57BL
Disease Models, Animal
Neurology
Cerebral blood flow
cardiovascular system
Cardiology
Neurovascular Coupling
Neurology (clinical)
Cardiology and Cardiovascular Medicine
business
030217 neurology & neurosurgery
circulatory and respiratory physiology
Subjects
Details
- ISSN :
- 15597016 and 0271678X
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Journal of Cerebral Blood Flow & Metabolism
- Accession number :
- edsair.doi.dedup.....d8318e05a29eb186ee98f717435867db