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A multi-tissue full lifespan epigenetic clock for mice
- Source :
- Aging (Albany NY)
- Publication Year :
- 2018
- Publisher :
- Impact Journals, LLC, 2018.
-
Abstract
- Human DNA-methylation data have been used to develop highly accurate biomarkers of aging ("epigenetic clocks"). Recent studies demonstrate that similar epigenetic clocks for mice (Mus Musculus) can be slowed by gold standard anti-aging interventions such as calorie restriction and growth hormone receptor knock-outs. Using DNA methylation data from previous publications with data collected in house for a total 1189 samples spanning 193,651 CpG sites, we developed 4 novel epigenetic clocks by choosing different regression models (elastic net- versus ridge regression) and by considering different sets of CpGs (all CpGs vs highly conserved CpGs). We demonstrate that accurate age estimators can be built on the basis of highly conserved CpGs. However, the most accurate clock results from applying elastic net regression to all CpGs. While the anti-aging effect of calorie restriction could be detected with all types of epigenetic clocks, only ridge regression based clocks replicated the finding of slow epigenetic aging effects in dwarf mice. Overall, this study demonstrates that there are trade-offs when it comes to epigenetic clocks in mice. Highly accurate clocks might not be optimal for detecting the beneficial effects of anti-aging interventions.
- Subjects :
- Male
0301 basic medicine
Elastic net regularization
Aging
Longevity
Calorie restriction
Dwarfism
Computational biology
Biology
Epigenesis, Genetic
03 medical and health sciences
0302 clinical medicine
Species Specificity
Biomarkers of aging
Biological Clocks
Databases, Genetic
Animals
Epigenetics
mouse
Caloric Restriction
Mice, Knockout
Sirolimus
Mice, Inbred BALB C
DNA methylation
Age Factors
Regression analysis
Cell Biology
Mice, Mutant Strains
Regression
biological age
Mice, Inbred C57BL
Disease Models, Animal
030104 developmental biology
CpG site
030220 oncology & carcinogenesis
CpG Islands
Female
epigenetic clock
Genome-Wide Association Study
Research Paper
Subjects
Details
- ISSN :
- 19454589
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Aging
- Accession number :
- edsair.doi.dedup.....d85af5fc13abd06df64b46b29d756e90