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Pancreatic duct changes are not associated with early signs of chronic pancreatitis at magnetic resonance imaging (MRI) in patients with primary sclerosing cholangitis
- Source :
- Scandinavian Journal of Gastroenterology. 45:980-986
- Publication Year :
- 2010
- Publisher :
- Informa UK Limited, 2010.
-
Abstract
- The association between chronic pancreatitis (CP) and primary sclerosing cholangitis (PSC) has been reported previously. The aims of the present study were to evaluate the presence of early pancreatic abnormalities and duct changes, using MRCP/MRI in PSC and to evaluate possible risk factors for these changes and their clinical importance.One hundred and three patients with PSC were identified among all MRI liver/pancreas referrals in 2001-2005. MRCP was used to grade pancreatic duct changes in three groups: grade 0 (normal), grade 1 (mild) and grade 2 (severe). For detection of early MRI signs of CP, the pancreas-spleen signal intensity ratio (SIR), the arterial and early venous phase ratio (A/PV ratio) and the age-related size of the pancreas were evaluated.Pancreatic duct changes were found in 24% of the PSC patients. The pancreatic duct changes were associated with extrahepatic biliary involvement and long duration of PSC but not associated with pancreas-spleen SIR, A/PV ratio, pancreas size, previous post-ERCP or acute pancreatitis. Severe pancreatic duct changes were significantly associated to abdominal pain. Clinically significant CP was seen in one PSC patient (1%).Pancreatic duct changes are associated with extrahepatic bile duct strictures and not with the early MRI signs of CP. Therefore, pancreatic duct changes seem to be part of the spectrum of PSC and should not be defined as CP. Pancreatic duct changes are of limited clinical importance but may contribute to abdominal pain in PSC.
- Subjects :
- Male
medicine.medical_specialty
Pancreatic disease
Early signs
Cholangitis, Sclerosing
Gastroenterology
Primary sclerosing cholangitis
Pancreatitis, Chronic
Internal medicine
medicine
Humans
Pancreatic duct
medicine.diagnostic_test
business.industry
Pancreatic Ducts
Magnetic resonance imaging
Middle Aged
medicine.disease
Magnetic Resonance Imaging
medicine.anatomical_structure
Pancreatitis
Female
sense organs
Pancreas
business
Duct (anatomy)
Subjects
Details
- ISSN :
- 15027708 and 00365521
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Scandinavian Journal of Gastroenterology
- Accession number :
- edsair.doi.dedup.....d85ed6554d9bd35a85b7b9f13947c400