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Complement component 7 is associated with total- and cardiac death in chest-pain patients with suspected acute coronary syndrome
- Source :
- BMC Cardiovascular Disorders, BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-12 (2021)
- Publication Year :
- 2021
-
Abstract
- Background Complement activation has been associated with atherosclerosis, atherosclerotic plaque destabilization and increased risk of cardiovascular events. Complement component 7 (CC7) binds to the C5bC6 complex which is part of the terminal complement complex (TCC/C5b-9). High-sensitivity C-reactive protein (hsCRP) is a sensitive marker of systemic inflammation and may reflect the increased inflammatory state associated with cardiovascular disease. Aim To evaluate the associations between CC7 and total- and cardiac mortality in patients hospitalized with chest-pain of suspected coronary origin, and whether combining CC7 with hsCRP adds prognostic information. Methods Baseline levels of CC7 were related to 60-months survival in a prospective, observational study of 982 patients hospitalized with a suspected acute coronary syndrome (ACS) at 9 hospitals in Salta, Argentina. A cox regression model, adjusting for conventional cardiovascular risk factors, was fitted with all-cause mortality, cardiac death and sudden cardiac death (SCD) as the dependent variables. A similar Norwegian population of 871 patients was applied to test the reproducibility of results in relation to total death. Results At follow-up, 173 patients (17.7%) in the Argentinean cohort had died, of these 92 (9.4%) were classified as cardiac death and 59 (6.0%) as SCD. In the Norwegian population, a total of 254 patients (30%) died. In multivariable analysis, CC7 was significantly associated with 60-months all-cause mortality [hazard ratio (HR) 1.26 (95% confidence interval (CI), 1.07–1.47) and cardiac death [HR 1.28 (95% CI 1.02–1.60)], but not with SCD. CC7 was only weakly correlated with hsCRP (r = 0.10, p = 0.002), and there was no statistically significant interaction between the two biomarkers in relation to outcome. The significant association of CC7 with total death was reproduced in the Norwegian population. Conclusions CC7 was significantly associated with all-cause mortality and cardiac death at 60-months follow-up in chest-pain patients with suspected ACS. Clinical trial registration ClinicalTrials.gov Identifier: NCT01377402, NCT00521976.
- Subjects :
- Male
medicine.medical_specialty
Acute coronary syndrome
Time Factors
Population
Argentina
Chest pain
Risk Assessment
Sudden cardiac death
Angina Pectoris
Predictive Value of Tests
Risk Factors
Internal medicine
Cause of Death
medicine
Diseases of the circulatory (Cardiovascular) system
Humans
Prospective Studies
Acute Coronary Syndrome
education
Cardiac death
Aged
Aged, 80 and over
education.field_of_study
Proportional hazards model
business.industry
Norway
Research
Hazard ratio
Complement component 7
Middle Aged
medicine.disease
Prognosis
All-cause mortality
Complement C7
Cardiac surgery
Hospitalization
High-sensitivity C-reactive protein
C-Reactive Protein
Prognostic biomarkers
RC666-701
Cardiology
Female
medicine.symptom
Inflammation Mediators
Cardiology and Cardiovascular Medicine
business
Biomarkers
Subjects
Details
- ISSN :
- 14712261
- Volume :
- 21
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC cardiovascular disorders
- Accession number :
- edsair.doi.dedup.....d86ac4babec79a3b586501b3bdf2bc8c