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Liver stem cells and their implication in hepatocellular and cholangiocarcinoma
- Source :
- Oncogene. 25:3818-3822
- Publication Year :
- 2006
- Publisher :
- Springer Science and Business Media LLC, 2006.
-
Abstract
- In the liver, several cell types have the longevity that is needed to be the cell of origin of a cancer: hepatocytes, cholangiocytes and progenitor cells. The latter are located in the most peripheral branches of the biliary tree, the ductules and canals of Hering. The most important risk factors for liver cancer are chronic viral hepatitis B and C and alcoholic and non-alcoholic steatohepatitis. In these and other chronic liver diseases, progenitor cell activation is seen, rendering them a target cell population for carcinogenesis. The degree of activation is positively correlated with the inflammatory activity and the stage of the disease. Recently, it has been shown that in the cirrhotic stage of most chronic liver diseases, the hepatocytes become senescent owing to telomere shortening. This makes it even more plausible that at least part of the hepatocellular carcinomas originate from a progenitor cell. Hepatocellular carcinomas expressing progenitor cell/ductular markers like cytokeratin 19 have a more aggressive clinical course. It is therefore important to recognize this entity.
- Subjects :
- Cancer Research
Carcinoma, Hepatocellular
Stem Cells
Liver Neoplasms
Cancer
Liver Stem Cell
Biology
medicine.disease
Cholangiocarcinoma
Bile Ducts, Intrahepatic
Bile Duct Neoplasms
Liver
Canals of Hering
Hepatocellular carcinoma
Genetics
medicine
Cancer research
Humans
Steatohepatitis
Stem cell
Progenitor cell
Liver cancer
Molecular Biology
Subjects
Details
- ISSN :
- 14765594 and 09509232
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Oncogene
- Accession number :
- edsair.doi.dedup.....d884cf21d9715358f1703502925bde11