Back to Search
Start Over
Recent increase in non-tuberculous mycobacterial infection in patients with connective tissue diseases in Japan
- Source :
- Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 26(9)
- Publication Year :
- 2019
-
Abstract
- Background Non-tuberculous mycobacterial (NTM) infection is currently a growing health concern due to the increasing incidence and the need for prolonged therapy. In patients with connective tissue diseases, use of immunosuppressants may lead to an increased risk of NTM infection. However, few studies have examined the recent incidence of NTM infection among connective tissue diseases patients. This study investigated recent trends in NTM infection among connective tissue diseases patients. Methods We included adult patients from whose cultures NTM were isolated between January 2009 and October 2017 in our hospital. By reviewing their medical records, connective tissue diseases patients were identified. Types of connective tissue disease, NTM species, and treatment of NTM infection were extracted. Results NTM was isolated from 657 patients during the period. Among these, 24 patients had connective tissue diseases. The number and rate of NTM isolates from connective tissue diseases patients increased during the period, with 4 patients 2009 to 2012 (1.9%), and 20 patients from 2013 to 2017 (3.3%; P = 0.04). The proportion of Mycobacterium avium complex (MAC) to total NTM tended to be lower among connective tissue diseases patients (58.3%) than among non-connective tissue disease-patients (72.8%), but the difference was not significant (P = 0.20). Mycobacterium xenopi was significantly more frequent in connective tissue disease patients than in non-connective tissue diseases patients (P Conclusion The recent increase in the incidence of NTM infections in connective tissue diseases patients was larger than that in the total population. NTM species other than MAC were isolated from connective tissue diseases patients.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
Non tuberculous mycobacterial
Adult
medicine.medical_specialty
030106 microbiology
Connective tissue
Mycobacterium Infections, Nontuberculous
03 medical and health sciences
0302 clinical medicine
Japan
Internal medicine
medicine
Humans
Pharmacology (medical)
Mycobacterium avium complex
In patient
030212 general & internal medicine
Mycobacterium xenopi
Connective Tissue Diseases
Retrospective Studies
biology
business.industry
Incidence (epidemiology)
Nontuberculous Mycobacteria
bacterial infections and mycoses
biology.organism_classification
medicine.disease
Mycobacterium avium Complex
Connective tissue disease
Infectious Diseases
medicine.anatomical_structure
Increased risk
business
Subjects
Details
- ISSN :
- 14377780
- Volume :
- 26
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
- Accession number :
- edsair.doi.dedup.....d897a0bb07d73fe4f91af5657af838b9