Back to Search
Start Over
Alcohol Drinking Pattern and Risk of Head and Neck Cancer: A Nationwide Cohort Study
- Source :
- International Journal of Environmental Research and Public Health, International Journal of Environmental Research and Public Health, Vol 18, Iss 11204, p 11204 (2021), Volume 18, Issue 21
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Alcohol consumption is a major risk factor for head and neck cancer (HNC), yet little data exist examining drinking patterns and HNC risk. In this population-based, retrospective cohort study, 11,737,467 subjects were recruited from the Korean National Health Insurance Service database. The risks of overall HNC and HNC subtypes according to average alcohol consumption, drinking frequency, and daily amount were examined using Cox proportional hazard models. Over the median follow-up of 6.4 years, 15,832 HNC cases were identified. HNC risk linearly increased with drinking frequency (p-trend &lt<br />0.01<br />adjusted hazard ratio [aHR] 1.55, 95% confidence interval [CI] 1.45–1.67 in subjects who drank 7 days/week). HNC risk also increased according to daily amount of alcohol consumption (p-trend &lt<br />0.01), but plateaued from 5–7 units/occasion (aHR 1.25, 95% CI 1.19–1.31) to &gt<br />14 units/occasion (aHR 1.26, 95% CI 1.13–1.40). When stratified by average alcohol consumption, drinking frequency, but not daily amount, showed a linear relationship with HNC risk in moderate and heavy drinkers. When comparing the HNC subtypes, similar tendencies were observed in cancers of the oral cavity, pharynx, and larynx, but not in the salivary gland. In conclusion, drinking frequency is a stronger risk factor for HNC, especially for cancer of the oral cavity, pharynx, and larynx, than the daily amount of alcohol consumption.
- Subjects :
- Larynx
medicine.medical_specialty
Health, Toxicology and Mutagenesis
Alcohol
Article
chemistry.chemical_compound
head and neck neoplasms
cohort studies
Internal medicine
medicine
Humans
risk factors
Risk factor
Retrospective Studies
business.industry
Pharynx
Head and neck cancer
drinking behavior
Public Health, Environmental and Occupational Health
Cancer
Retrospective cohort study
medicine.disease
alcohol drinking
medicine.anatomical_structure
chemistry
Carcinoma, Squamous Cell
Medicine
business
Cohort study
Subjects
Details
- ISSN :
- 16604601
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- International Journal of Environmental Research and Public Health
- Accession number :
- edsair.doi.dedup.....d8988d213dc084576afd1c961432e13f