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Molecular insight into odontogenesis in hyperglycemic environment: A systematic review
- Source :
- Journal of Pharmacy & Bioallied Sciences, Journal of Pharmacy and Bioallied Sciences, Vol 12, Iss 5, Pp 49-56 (2020)
- Publication Year :
- 2020
- Publisher :
- Medknow, 2020.
-
Abstract
- Diabetes mellitus is an endocrinal disorder affecting worldwide and the disease incidence is rising alarmingly high. The effects of diabetes on tooth development are explored by limited studies and their molecular insights are very rarely studied. This systematic review is aimed to provide the best scientific literature source on the molecular insights into odontogenesis in hyperglycemic environment caused by diabetes mellitus or by maternal diabetes on the offspring. The literature search was conducted on the databases, namely PubMed, PubMed Central, Cochrane, and Scopus. The original studies exploring the alterations in the molecular pathways of odontogenesis in diabetes mellitus were selected. Data were extracted, chosen, and evaluated by two independent researchers. At the end of thorough data search, four articles were eligible for the review. Three articles brought out the molecular pathways involved in the offspring of gestational diabetes through animal models. Fourth article was an in vitro study, which treated the stem cells in hyperglycemic environment and drafted the molecular pathway. The altered molecular pathways in dental epithelial stem cells (DESCs), dental papilla cells (DPCs), and stem cells from apical papilla were studied and empowered with statistical analysis. Thus with this systematic review, we conclude that apurinic/apyrimidinic endonuclease1 downregulation causing deoxyribonucleic acid hypermethylation and Oct4, Nanog gene silencing, activation of toll-like receptor-4/nuclear factor kappa B (TLR4/NF-κB) pathway are involved in suppressing cell proliferation and accelerated apoptosis in DESCs in high glucose environment. DPCs are suppressed from odonto differentiation by activation of TLR4 signaling and resulting inhibition of SMAD1/5/9 phosphorylation in diabetic condition. NF-κB pathway activation causes decreased cell proliferation and enhanced differentiation in apical papilla stem cells in hyperglycemia. Further studies targeting various stages of odontogenesis can reveal more molecular insight.
- Subjects :
- Homeobox protein NANOG
lcsh:Analytical chemistry
lcsh:RS1-441
Bioengineering
Review Article
Biology
General Biochemistry, Genetics and Molecular Biology
lcsh:Pharmacy and materia medica
03 medical and health sciences
Diabetes mellitus
0302 clinical medicine
Downregulation and upregulation
medicine
Gene silencing
030212 general & internal medicine
General Pharmacology, Toxicology and Pharmaceutics
maternal diabetes
Dental papilla
lcsh:QD71-142
tooth development
030206 dentistry
medicine.disease
Gestational diabetes
DNA methylation
Cancer research
odontogenesis
hyperglycemia
Stem cell
Subjects
Details
- ISSN :
- 09757406
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Journal of Pharmacy And Bioallied Sciences
- Accession number :
- edsair.doi.dedup.....d8a46ab4f1828290e718d55529d1cfec