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A genome-wide association analysis identifies NMNAT2 and HCP5 as susceptibility loci for Kawasaki disease

Authors :
Jae-Jung, Kim
Sin Weon, Yun
Jeong Jin, Yu
Kyung Lim, Yoon
Kyung-Yil, Lee
Hong-Ryang, Kil
Gi Beom, Kim
Myung-Ki, Han
Min Seob, Song
Hyoung Doo, Lee
Kee Soo, Ha
Sejung, Sohn
Todd A, Johnson
Atsushi, Takahashi
Michiaki, Kubo
Tatsuhiko, Tsunoda
Kaoru, Ito
Yoshihiro, Onouchi
Young Mi, Hong
Gi Young, Jang
Jong-Keuk, Lee
Jong-Duk, Kim
Source :
Journal of human genetics. 62(12)
Publication Year :
2017

Abstract

Kawasaki disease (KD), a systemic vasculitis of infants and children, manifests as fever and mucocutaneous inflammation. Although its etiology is largely unknown, the epidemiological data suggest that genetic factors are important in KD susceptibility. To identify genetic variants influencing KD susceptibility, we performed a genome-wide association study (GWAS) and replication study using a total of 915 children with KD and 4553 controls in the Korean population. Six single-nucleotide polymorphisms (SNPs) in three loci were associated significantly with KD susceptibility (P

Details

ISSN :
1435232X
Volume :
62
Issue :
12
Database :
OpenAIRE
Journal :
Journal of human genetics
Accession number :
edsair.doi.dedup.....d8b024739254ac2ee59c2384d7bcc256