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Irreversible electroporation versus radiotherapy after induction chemotherapy on survival in patients with locally advanced pancreatic cancer: a propensity score analysis
- Source :
- BMC Cancer, Vol 19, Iss 1, Pp 1-11 (2019), BMC Cancer
- Publication Year :
- 2019
- Publisher :
- BMC, 2019.
-
Abstract
- Background Locally advanced pancreatic cancer (LAPC) represents more than one third of pancreatic cancers and owns poor survival after the standard chemotherapy. Irreversible electroporation (IRE) is a novel method and has been recently used in LAPC. The aim of this study was to compare the efficacy of IRE and radiotherapy after induction chemotherapy for patients with LAPC. Methods From August 2015 to August 2017, a total of 76 patients with biopsy proven LAPC and who had received IRE or radiotherapy after chemotherapy were included. Thirty-two pairs of patients were selected through propensity score matching (PSM) analysis and the efficacy of two treatments was compared. Results Before PSM analysis, after induction chemotherapy, patients with LAPC benefited more in terms of overall survival (OS) and progression free survival (PFS) from IRE, compared with radiotherapy (2-year OS rates, 53.5% vs 26.9%, p = 0.039; 2-year PFS rates, 28.4% vs 13.3%, p = 0.045). After PSM analysis, the survival benefits of OS and PFS of patients after induction chemotherapy followed by IRE were more obvious than those of patients treated with radiotherapy (2-year OS rates, 53.5% vs 20.7%, p = 0.011; 2-year PFS rates, 28.4% vs 5.6%, p = 0.004). Multivariate Cox regression analysis indicated that IRE after induction chemotherapy was identified as a significant favourable factor for both OS and PFS in both the whole and matched cohort. Conclusions Induction chemotherapy followed by IRE is superior to induction chemotherapy followed by radiotherapy for treating LAPC. A randomized clinical trial comparing the efficacy of IRE and radiotherapy after the induction chemotherapy is therefore considerable.
- Subjects :
- Adult
Male
0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
Efficacy
medicine.medical_treatment
Locally advanced pancreatic cancer
Kaplan-Meier Estimate
lcsh:RC254-282
03 medical and health sciences
0302 clinical medicine
Surgical oncology
Internal medicine
Irreversible electroporation
Antineoplastic Combined Chemotherapy Protocols
Genetics
Humans
Medicine
Chemotherapy
Progression-free survival
Propensity Score
Pancreas
Aged
Radiotherapy
business.industry
Proportional hazards model
fungi
Induction chemotherapy
Induction Chemotherapy
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Combined Modality Therapy
Progression-Free Survival
Pancreatic Neoplasms
Radiation therapy
Electroporation
030104 developmental biology
030220 oncology & carcinogenesis
Propensity score matching
Female
business
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 14712407
- Volume :
- 19
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Cancer
- Accession number :
- edsair.doi.dedup.....d8c3bfb8995579b412eb8f43282539d6