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Evidence for Circulating Immune Complexes in Thyroid Disease
- Publication Year :
- 1974
-
Abstract
- Anti-complementary activity was detected in the sera of 23 (59%) out of 39 patients with Hashimoto thyroiditis; in 10 (29%) out of 34 patients with primary hypothyroidism; in six (17%) out of 36 patients with thyrotoxicosis; and in only six (8%) out of 78 control subjects. Fractionation of Hashimoto sera by Sephadex G-200 chromatography showed that the anti-complementary activity was founding fractions of larger molecular size than monomeric IgG, being localized predominantly in the ascending limb of the second elution peak, suggesting that it was in the form of small immune complexes.
- Subjects :
- medicine.medical_specialty
endocrine system
endocrine system diseases
Guinea Pigs
Antigen-Antibody Complex
Hyperthyroidism
Thyroiditis
Immunoglobulin G
Immune system
Hypothyroidism
Internal medicine
Medicine
Animals
Humans
Immune adherence reaction
General Environmental Science
Complement Inactivator Proteins
Sheep
biology
business.industry
Thyroid disease
General Engineering
Primary hypothyroidism
Thyroiditis, Autoimmune
General Medicine
Papers and Originals
medicine.disease
Thyroid Diseases
Immune Adherence Reaction
Antibodies, Anti-Idiotypic
Molecular Weight
Endocrinology
Sephadex
biology.protein
Chromatography, Gel
General Earth and Planetary Sciences
Binding Sites, Antibody
Antibody
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....d8cab21c8de8341005174153bfc70acb