Back to Search
Start Over
Ethanol Extracts from Thai Plants have Anti-Plasmodium and Anti-Toxoplasma Activities In Vitro
- Source :
- Acta Parasitologica. 64:257-261
- Publication Year :
- 2019
- Publisher :
- Walter de Gruyter GmbH, 2019.
-
Abstract
- application/pdf<br />Purpose: The ethanol extracts from seven Thai plants, Kaempferia parviflora, Stemona tuberosa Lour., Ananas comosus, Punica granatum, Musa sapientum L., Pseuderanthemum palatiferum and Annona muricata L., which are traditionally used in Thailand to support human health, were evaluated for their anti-Plasmodium and anti-Toxoplasma activities, and for their cytotoxicities against human foreskin fibroblasts in vitro. Results: The K. parviflora, P. palatiferum and A. muricata extracts were active against P. falciparum (3D7) with selectivity index (SI) values > 10, while their half maximal inhibitory concentrations (IC50) were 28.7 µg/ml, 78.8 µg/ml and 46.1 µg/ml, respectively. Extracts from K. parviflora and M. sapientum (ripe fruit peel) inhibited T. gondii (RH) growth with IC50 values of 53.5 µg/ml and 90.4 µg/ml, respectively. The SI values of the extracts from K. parviflora and M. sapientum (ripe fruit peel) were 9.0 and 10.8, respectively. Conclusion: Our data show that some of the aforementioned ethanol extracts are potential sources of new drugs to treat Plasmodium and Toxoplasma infections. © 2019, Witold StefaĆski Institute of Parasitology, Polish Academy of Sciences.
- Subjects :
- Plasmodium
Pseuderanthemum
Plasmodium falciparum
ved/biology.organism_classification_rank.species
Antiprotozoal Agents
Toxoplasma gondii
Biology
Antimalarials
Inhibitory Concentration 50
parasitic diseases
Humans
Malaria, Falciparum
Ananas
IC50
Annona muricata
Natural plants
Kaempferia parviflora
Ethanol
Traditional medicine
Plant Extracts
ved/biology
Fibroblasts
Thailand
biology.organism_classification
Punica
Parasitology
Toxoplasma
Stemona tuberosa
Subjects
Details
- ISSN :
- 18961851 and 12302821
- Volume :
- 64
- Database :
- OpenAIRE
- Journal :
- Acta Parasitologica
- Accession number :
- edsair.doi.dedup.....d8cedb0d24fd4c0a6932ff2a6774dd6b