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Family cord blood banking for sickle cell disease: a twenty-year experience in two dedicated public cord blood banks
Family cord blood banking for sickle cell disease: a twenty-year experience in two dedicated public cord blood banks
- Source :
- Haematologica
- Publication Year :
- 2017
- Publisher :
- Ferrata Storti Foundation (Haematologica), 2017.
-
Abstract
- Efforts to implement family cord blood banking have been developed in the past decades for siblings requiring stem cell transplantation for conditions such as sickle cell disease. However, public banks are faced with challenging decisions about the units to be stored, discarded, or used for other endeavors. We report here 20 years of experience in family cord blood banking for sickle cell disease in two dedicated public banks. Participants were pregnant women who had a previous child diagnosed with homozygous sickle cell disease. Participation was voluntary and free of charge. All mothers underwent mandatory serological screening. Cord blood units were collected in different hospitals, but processed and stored in two public banks. A total of 338 units were stored for 302 families. Median recipient age was six years (11 months-15 years). Median collected volume and total nucleated cell count were 91 mL (range 23–230) and 8.6×108 (range 0.7–75×108), respectively. Microbial contamination was observed in 3.5% (n=12), positive hepatitis B serology in 25% (n=84), and homozygous sickle cell disease in 11% (n=37) of the collections. Forty-four units were HLA-identical to the intended recipient, and 28 units were released for transplantation either alone (n=23) or in combination with the bone marrow from the same donor (n=5), reflecting a utilization rate of 8%. Engraftment rate was 96% with 100% survival. Family cord blood banking yields good quality units for sibling transplantation. More comprehensive banking based on close collaboration among banks, clinical and transplant teams is recommended to optimize the use of these units.
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
Pediatrics
Adolescent
Anemia
Anemia, Sickle Cell
Article
Young Adult
03 medical and health sciences
0302 clinical medicine
Pregnancy
medicine
Humans
Family
Red Cell Biology & its Disorders
Sibling
Young adult
Child
Survival rate
business.industry
Siblings
Graft Survival
Infant
Hematology
Fetal Blood
medicine.disease
Tissue Donors
3. Good health
Surgery
Survival Rate
Transplantation
030104 developmental biology
medicine.anatomical_structure
Child, Preschool
Histocompatibility
Cord blood
Blood Banks
Female
Cord Blood Stem Cell Transplantation
Bone marrow
business
030215 immunology
Subjects
Details
- ISSN :
- 15928721 and 03906078
- Volume :
- 102
- Database :
- OpenAIRE
- Journal :
- Haematologica
- Accession number :
- edsair.doi.dedup.....d8cf179f763bbd4b4f22d350e6fde783
- Full Text :
- https://doi.org/10.3324/haematol.2016.163055