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Sordarin Oxazepine Derivatives as Potent Antifungal Agents
- Source :
- Bioorganic & Medicinal Chemistry Letters. 12:2757-2760
- Publication Year :
- 2002
- Publisher :
- Elsevier BV, 2002.
-
Abstract
- The synthesis and biological activity of sordarin oxazepine derivatives are described. The key step features a regioselective oxidation of an unprotected triol followed by double reductive amination to afford the ring-closed products. The spectrum of antifungal activity for these novel derivatives includes coverage of Candida albicans, Candida glabrata, and Cryptococcus neoformans.
- Subjects :
- Antifungal Agents
Stereochemistry
Clinical Biochemistry
Pharmaceutical Science
Candida glabrata
Microbial Sensitivity Tests
Biochemistry
Chemical synthesis
Reductive amination
Structure-Activity Relationship
chemistry.chemical_compound
Candida albicans
Drug Discovery
Molecular Biology
Cryptococcus neoformans
biology
Organic Chemistry
Fungi
Hydrogen Bonding
Biological activity
biology.organism_classification
Oxazepines
Indenes
chemistry
Molecular Medicine
Oxazepine
Triol
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....d8d37939ab96f1503179b9da7aee68e1