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Optical Coherence Tomography of the Retinal Ganglion Cell Complex in Leber's Hereditary Optic Neuropathy and Dominant Optic Atrophy
- Source :
- Current eye research. 44(6)
- Publication Year :
- 2019
-
Abstract
- Background: Mitochondrial optic neuropathies such as Leber's Hereditary Optic Neuropathy (LHON) and Dominant Optic Atrophy (DOA) have been shown to produce an optic neuropathy secondary to retinal ganglion cell loss with thinning of the retinal ganglion cell complex (RGCC). Methods: We performed a retrospective analysis assessing the thicknesses of the peripapillary retinal nerve fiber layer (pRNFL) along with the macular retinal ganglion cell-inner plexiform layer (RGC-IPL) using optical coherence tomography (OCT). We compared these changes among acute and chronic LHON, DOA, and normal healthy control patients. Results: Patients with chronic LHON exhibited statistically significant thinning of the RNFL in the superior, nasal, and inferior quadrants of the retina. In acute LHON, the RNFL was relatively thicker in all but the temporal quadrant when compared with respective quadrants in normal eyes; however, statistical significance was not achieved. In DOA, the RNFL was thinnest in the superior and inferior quadrants of the retina, measuring between acute and chronic LHON thickness values. In chronic LHON and DOA, both the pRNFL and RGC-IPL were significantly thinner in all four retinal quadrants relative to controls. Conclusions: This article represents the first comparative study of the RGCC between LHON and DOA. Our findings demonstrated significant thickness reductions in pRNFL and macular RGC-IPL in patients with LHON and DOA, with different specific patterns consistent with the general patterns of thinning classically observed. This study suggests the usefulness of the RGCC as a potential in vivo biomarker for assessing disease in patients with LHON and DOA.
- Subjects :
- Adult
Male
Retinal Ganglion Cells
congenital, hereditary, and neonatal diseases and abnormalities
medicine.medical_specialty
Mitochondrial Diseases
genetic structures
Adolescent
Nerve fiber layer
Visual Acuity
Optic Atrophy, Hereditary, Leber
Retinal ganglion
Optic neuropathy
03 medical and health sciences
Cellular and Molecular Neuroscience
Young Adult
0302 clinical medicine
Nerve Fibers
Ophthalmology
Optic Atrophy, Autosomal Dominant
medicine
Humans
Aged
Retrospective Studies
Retina
business.industry
Leber's hereditary optic neuropathy
Middle Aged
medicine.disease
eye diseases
Sensory Systems
medicine.anatomical_structure
Cross-Sectional Studies
Retinal ganglion cell
Acute Disease
Chronic Disease
030221 ophthalmology & optometry
Optic nerve
Female
sense organs
Mitochondrial optic neuropathies
business
030217 neurology & neurosurgery
Tomography, Optical Coherence
Subjects
Details
- ISSN :
- 14602202
- Volume :
- 44
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Current eye research
- Accession number :
- edsair.doi.dedup.....d91e9377c38e26d815bde223ed3ff131