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Acute toxicity in 14 patients with locally advanced head and neck squamous cell carcinoma treated with concurrent cetuximab and radiotherapy
- Source :
- La Radiologia medica. 117(1)
- Publication Year :
- 2010
-
Abstract
- The authors report acute toxicity in 14 patients with locally advanced head and neck squamous cell carcinoma treated with radiotherapy and cetuximab.Data collection was performed prospectively on patients treated from September 2007 to March 2009. Treatment consisted of 64.8-70 Gy radiotherapy in conventional fractions and cetuximab.Two out of 14 patients did not complete the planned combined treatment; radiotherapy was temporarily suspended in six other patients. Seven of 12 patients received cetuximab until the end of radiotherapy. Treatment breaks were principally due to severe acute cutaneous or mucous toxicity. Any grade acneiform rash occurred in all patients. In-field G3-4 cutaneous toxicity occurred in five (36%) patients and G3-4 mucous toxicity in seven (50%). One patient died of sepsis.In our experience, severe acute toxic reactions are common in patients treated with radiotherapy and concurrent cetuximab, resulting in frequent breaks or incomplete treatment with potential reduction in disease control.
- Subjects :
- Oncology
Adult
Male
medicine.medical_specialty
medicine.medical_treatment
Locally advanced
Cetuximab
Antineoplastic Agents
adult
adverse effects
aged
antibodies
antineoplastic agents
carcinoma
combined modality therapy
dose-response relationship
drug therapy/radiotherapy
epidemiology
female
head and neck neoplasms
humans
italy
male
middle aged
monoclonal
prospective studies
radiation
radiodermatitis
squamous cell
survival rate
therapeutic use
treatment outcome
Head and neck tumours
Radiotherapy
Toxicity
Antibodies, Monoclonal, Humanized
Internal medicine
medicine
Humans
Radiology, Nuclear Medicine and imaging
Prospective Studies
neoplasms
Neuroradiology
Aged
medicine.diagnostic_test
business.industry
Antibodies, Monoclonal
Interventional radiology
Dose-Response Relationship, Radiation
General Medicine
Middle Aged
medicine.disease
Head and neck squamous-cell carcinoma
Combined Modality Therapy
digestive system diseases
Acute toxicity
Radiation therapy
Survival Rate
Treatment Outcome
Italy
Head and Neck Neoplasms
Carcinoma, Squamous Cell
Female
Radiodermatitis
business
medicine.drug
Subjects
Details
- ISSN :
- 18266983
- Volume :
- 117
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- La Radiologia medica
- Accession number :
- edsair.doi.dedup.....d927028459e37f66a50311f46e01c813