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Low-intensity exercise diverts cardiac fatty acid metabolism from triacylglycerol synthesis to beta oxidation in fructose-fed rats
- Source :
- Archives of Physiology and Biochemistry. :1-11
- Publication Year :
- 2021
- Publisher :
- Informa UK Limited, 2021.
-
Abstract
- Excessive fructose consumption causes ectopic lipid storage leading to metabolic disorders and cardiovascular diseases associated with defective substrate utilisation in the heart.Examining the preventive impact of low-intensity exercise on alterations related to fructose-rich diet (FRD) on cardiac fatty acid (FA) transport and metabolism.Male Wistar rats were divided into control and two groups that received 10% fructose for 9 weeks, one of which was additionally exposed to exercise.FRD elevated plasma and cardiac TAG, FATP1 in plasma membrane, Lipin 1 in microsomes and HSL mRNA, while mitochondrial CPT1 was decreased. Exercise decreased plasma free FA level, raised CD36 in plasma membrane and FATP1 in lysate, mitochondrial CPT1 and decreased microsomal Lipin 1 in fructose-fed rats.FRD changed plasma lipids and augmented partitioning of FA to TAG storage in the heart, whereas exercise in FRD rats switched metabolism of FA towards β-oxidation.
- Subjects :
- Fructose fed rats
Fatty acid metabolism
Physiology
Substrate (chemistry)
030209 endocrinology & metabolism
Fructose
General Medicine
Lipid storage
3. Good health
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
chemistry
030220 oncology & carcinogenesis
Physiology (medical)
Low intensity exercise
Food science
Beta oxidation
Subjects
Details
- ISSN :
- 17444160 and 13813455
- Database :
- OpenAIRE
- Journal :
- Archives of Physiology and Biochemistry
- Accession number :
- edsair.doi.dedup.....d9315fe529d8f9e3cc59f325e6a22231