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Arsenic Secondary Methylation Capacity Is Inversely Associated with Arsenic Exposure-Related Muscle Mass Reduction
Arsenic Secondary Methylation Capacity Is Inversely Associated with Arsenic Exposure-Related Muscle Mass Reduction
- Source :
- International Journal of Environmental Research and Public Health, Volume 18, Issue 18, International Journal of Environmental Research and Public Health, Vol 18, Iss 9730, p 9730 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Skeletal muscle mass reduction has been implicated in insulin resistance (IR) that promotes cardiometabolic diseases. We have previously reported that arsenic exposure increases IR concomitantly with the reduction of skeletal muscle mass among individuals exposed to arsenic. The arsenic methylation capacity is linked to the susceptibility to some arsenic exposure-related diseases. However, it remains unknown whether the arsenic methylation capacity affects the arsenic-induced reduction of muscle mass and elevation of IR. Therefore, this study examined the associations between the arsenic methylation status and skeletal muscle mass measures with regard to IR by recruiting 437 participants from low- and high-arsenic exposure areas in Bangladesh. The subjects’ skeletal muscle mass was estimated by their lean body mass (LBM) and serum creatinine levels. Subjects’ drinking water arsenic concentrations were positively associated with total urinary arsenic concentrations and the percentages of MMA, as well as inversely associated with the percentages of DMA and the secondary methylation index (SMI). Subjects’ LBM and serum creatinine levels were positively associated with the percentage of DMA and SMI, as well as inversely associated with the percentage of MMA. HOMA-IR showed an inverse association with SMI, with a confounding effect of sex. Our results suggest that reduced secondary methylation capacity is involved in the arsenic-induced skeletal muscle loss that may be implicated in arsenic-induced IR and cardiometabolic diseases.
- Subjects :
- inorganic chemicals
medicine.medical_specialty
Health, Toxicology and Mutagenesis
Urinary system
chemistry.chemical_element
Methylation
Arsenicals
Article
chemistry.chemical_compound
Insulin resistance
insulin resistance
Internal medicine
Diabetes mellitus
medicine
Humans
Muscle, Skeletal
metabolites
Arsenic
Creatinine
cardiometabolic disease
diabetes
integumentary system
arsenic
Public Health, Environmental and Occupational Health
Skeletal muscle
Environmental Exposure
medicine.disease
Endocrinology
medicine.anatomical_structure
muscle mass
chemistry
Lean body mass
Medicine
Subjects
Details
- ISSN :
- 16604601
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- International Journal of Environmental Research and Public Health
- Accession number :
- edsair.doi.dedup.....d9407fbdfa5ee4ad667ba3a7f5151a7a
- Full Text :
- https://doi.org/10.3390/ijerph18189730