Back to Search Start Over

Arsenic Secondary Methylation Capacity Is Inversely Associated with Arsenic Exposure-Related Muscle Mass Reduction

Arsenic Secondary Methylation Capacity Is Inversely Associated with Arsenic Exposure-Related Muscle Mass Reduction

Authors :
Zohurul Islam
Abu Eabrahim Siddique
Hideki Miyataka
Seiichiro Himeno
Khaled Hossain
Shakhawoat Hossain
Md. Khalequzzaman Sarker
Selim Reza Tony
Md. Shofikul Islam
Md. Rezaul Karim
Moriom Khatun
Nazmul Haque
Zahangir Alam Saud
Daigo Sumi
Jahidul Islam
Aaron Barchowsky
Source :
International Journal of Environmental Research and Public Health, Volume 18, Issue 18, International Journal of Environmental Research and Public Health, Vol 18, Iss 9730, p 9730 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Skeletal muscle mass reduction has been implicated in insulin resistance (IR) that promotes cardiometabolic diseases. We have previously reported that arsenic exposure increases IR concomitantly with the reduction of skeletal muscle mass among individuals exposed to arsenic. The arsenic methylation capacity is linked to the susceptibility to some arsenic exposure-related diseases. However, it remains unknown whether the arsenic methylation capacity affects the arsenic-induced reduction of muscle mass and elevation of IR. Therefore, this study examined the associations between the arsenic methylation status and skeletal muscle mass measures with regard to IR by recruiting 437 participants from low- and high-arsenic exposure areas in Bangladesh. The subjects’ skeletal muscle mass was estimated by their lean body mass (LBM) and serum creatinine levels. Subjects’ drinking water arsenic concentrations were positively associated with total urinary arsenic concentrations and the percentages of MMA, as well as inversely associated with the percentages of DMA and the secondary methylation index (SMI). Subjects’ LBM and serum creatinine levels were positively associated with the percentage of DMA and SMI, as well as inversely associated with the percentage of MMA. HOMA-IR showed an inverse association with SMI, with a confounding effect of sex. Our results suggest that reduced secondary methylation capacity is involved in the arsenic-induced skeletal muscle loss that may be implicated in arsenic-induced IR and cardiometabolic diseases.

Details

ISSN :
16604601
Volume :
18
Database :
OpenAIRE
Journal :
International Journal of Environmental Research and Public Health
Accession number :
edsair.doi.dedup.....d9407fbdfa5ee4ad667ba3a7f5151a7a
Full Text :
https://doi.org/10.3390/ijerph18189730