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Naloxegol in opioid-induced constipation: a new paradigm in the treatment of a common problem
- Source :
- Patient preference and adherence
- Publication Year :
- 2017
- Publisher :
- Informa UK Limited, 2017.
-
Abstract
- Opioid-induced constipation (OIC) imposes a significant burden for patients taking pain medications, often resulting in decreased quality of life. Treatment of OIC with traditional medications for functional constipation can be incompletely effective, leading to nonadherence with opioid treatment and undertreated pain. An emerging class of medications that counteract the adverse effects of opioids in the gastrointestinal tract while preserving central nervous system-based pain relief may represent a paradigm shift in the prevention and treatment of OIC. One of these medications, naloxegol, is a once-daily, oral opioid antagonist that is effective, well-tolerated, and approved for treatment of OIC in patients with noncancer pain. More studies are needed to demonstrate this same utility in patients with cancer-related pain.
- Subjects :
- medicine.medical_specialty
Constipation
medicine.drug_class
Medicine (miscellaneous)
Review
peripherally acting mu-opioid-receptor antagonist
03 medical and health sciences
Naloxegol
chemistry.chemical_compound
OIBD
0302 clinical medicine
medicine
Intensive care medicine
Adverse effect
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
business.industry
Health Policy
Chronic pain
bowel care
medicine.disease
opioid-induced constipation
chemistry
Opioid
030220 oncology & carcinogenesis
Functional constipation
Bowel care
medicine.symptom
chronic pain
business
030217 neurology & neurosurgery
Social Sciences (miscellaneous)
Opioid antagonist
medicine.drug
Subjects
Details
- ISSN :
- 1177889X
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Patient Preference and Adherence
- Accession number :
- edsair.doi.dedup.....d94851893e06bdf8c2087bc77e5ed7fb