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Serum soluble CD40 is associated with liver injury in patients with chronic hepatitis B

Authors :
Hai-Li Huang
Bao-sen Li
Yan Hu
Jun Hou
Bing-ke Bai
Hong-hui Shen
Jing-min Zhao
Pan-yong Mao
Ya-Qing Wang
Guang-De Zhou
Source :
Experimental and Therapeutic Medicine
Publication Year :
2015
Publisher :
Spandidos Publications, 2015.

Abstract

Soluble cluster of differentiation 40 (sCD40) is proteolytically cleaved from membrane-bound CD40 and binds to CD154, thereby inhibiting CD40-CD154-mediated immune responses. The aim of the present study was to clarify the role of sCD40 in chronic hepatitis B (CHB). The sCD40 levels in sera from 132 patients with CHB and 33 healthy individuals were retrospectively measured. sCD40 concentrations in patients with CHB were higher than those in healthy controls, and sCD40 levels correlated positively with serum levels of the liver dysfunction biomarkers alanine transaminase (ALT) and aspartate transaminase (AST). sCD40 concentrations increased with a rise in the severity of liver necroinflammation and fibrosis. Patients with >75% liver tissue staining positive for hepatitis B virus (HBV) antigen expression showed significantly lower sCD40 levels than those who stained negative for the HBV antigen. The area under the receiver operating characteristic curve of sCD40 was greater than that of ALT and AST; thus, sCD40 levels have a high diagnostic accuracy for detecting severe liver inflammation in patients with CHB, and could serve as an immunological marker of hepatic tissue injury.

Details

ISSN :
17921015 and 17920981
Volume :
9
Database :
OpenAIRE
Journal :
Experimental and Therapeutic Medicine
Accession number :
edsair.doi.dedup.....d951bfaec39b1ea1fd2a6f4436f44135
Full Text :
https://doi.org/10.3892/etm.2015.2182