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Oxytocin can hinder trust and cooperation in borderline personality disorder
- Source :
- Social Cognitive and Affective Neuroscience. 6:556-563
- Publication Year :
- 2010
- Publisher :
- Oxford University Press (OUP), 2010.
-
Abstract
- We investigated the effects of intranasal oxytocin (OXT) on trust and cooperation in borderline personality disorder (BPD), a disorder marked by interpersonal instability and difficulties with cooperation. Although studies in healthy adults show that intranasal OXT increases trust, individuals with BPD may show an altered response to exogenous OXT because the effects of OXT on trust and pro-social behavior may vary depending on the relationship representations and expectations people possess and/or altered OXT system functioning in BPD. BPD and control participants received intranasal OXT and played a social dilemma game with a partner. Results showed that OXT produced divergent effects in BPD participants, decreasing trust and the likelihood of cooperative responses. Additional analyses focusing on individual differences in attachment anxiety and avoidance across BPD and control participants indicate that these divergent effects were driven by the anxiously attached, rejection-sensitive participants. These data suggest that OXT does not uniformly facilitate trust and pro-social behavior in humans; indeed, OXT may impede trust and pro-social behavior depending on chronic interpersonal insecurities, and/or possible neurochemical differences in the OXT system. Although popularly dubbed the ‘hormone of love’, these data suggest a more circumspect answer to the question of who will benefit from OXT.
- Subjects :
- Adult
Male
Cognitive Neuroscience
Individuality
Experimental and Cognitive Psychology
Attachment anxiety
Interpersonal communication
Oxytocin
Trust
behavioral disciplines and activities
Developmental psychology
Neurochemical
Borderline Personality Disorder
Surveys and Questionnaires
mental disorders
medicine
Humans
Cooperative Behavior
Social Behavior
Borderline personality disorder
Analysis of Variance
Extramural
Original Articles
General Medicine
Social dilemma
medicine.disease
Games, Experimental
Female
Cooperative behavior
Psychology
hormones, hormone substitutes, and hormone antagonists
medicine.drug
Subjects
Details
- ISSN :
- 17495024 and 17495016
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Social Cognitive and Affective Neuroscience
- Accession number :
- edsair.doi.dedup.....d95fab77d2fef2d92018bb17d42688a3
- Full Text :
- https://doi.org/10.1093/scan/nsq085