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Reactive Oxygen Species and Glutathione Dual Redox-Responsive Supramolecular Assemblies with Controllable Release Capability
- Source :
- ACS applied materialsinterfaces. 9(5)
- Publication Year :
- 2017
-
Abstract
- A dual redox and biorelevant triggered supramolecular system is developed through noncovalent supramolecular inclusion interactions between the ferrocene (Fc) modified on camptothecin (CPT) and β-cyclodextrin (β-CD) at the end of methoxy polyethylene glycol (mPEG). With these two segments, a stable noncovalent supramolecular structure, i.e., mPEG-β-CD/Fc-CPT, can be formed, and then self-assembled into micellar structures in water. Interestingly, these supramolecular micelles showed uniform sphere structure, high and constant drug loading content, hyper-fast redox-responsive drug release, and exhibited equal cellular proliferation inhibition toward A549 cancer cells. The cytotoxicity evaluation of mPEG-β-CD also indicated good biocompatibility. In vivo results revealed the mPEG-β-CD/Fc-CPT nanoparticles had higher in vivo efficacy without side effects. It is anticipated this supramolecular complex may serve as a new kind of promising alternative for drug delivery systems.
- Subjects :
- Materials science
Biocompatibility
Stereochemistry
technology, industry, and agriculture
Supramolecular chemistry
macromolecular substances
02 engineering and technology
Polyethylene glycol
010402 general chemistry
021001 nanoscience & nanotechnology
01 natural sciences
Micelle
Combinatorial chemistry
Redox
0104 chemical sciences
chemistry.chemical_compound
chemistry
In vivo
Drug delivery
medicine
General Materials Science
0210 nano-technology
Camptothecin
medicine.drug
Subjects
Details
- ISSN :
- 19448252
- Volume :
- 9
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- ACS applied materialsinterfaces
- Accession number :
- edsair.doi.dedup.....d96310dffe2d555d3ac371ae18427353