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Light stimuli control neuronal migration by altering of insulin-like growth factor 1 (IGF-1) signaling
- Source :
- Proceedings of the National Academy of Sciences of the United States of America. 109(7)
- Publication Year :
- 2012
-
Abstract
- The role of genetic inheritance in brain development has been well characterized, but little is known about the contributions of natural environmental stimuli, such as the effect of light–dark cycles, to brain development. In this study, we determined the role of light stimuli in neuronal cell migration to elucidate how environmental factors regulate brain development. We show that in early postnatal mouse cerebella, granule cell migration accelerates during light cycles and decelerates during dark cycles. Furthermore, cerebellar levels of insulin-like growth factor 1 (IGF-1) are high during light cycles and low during dark cycles. There are causal relationships between light–dark cycles, speed of granule cell migration, and cerebellar IGF-1 levels. First, changes in light–dark cycles result in corresponding changes in the fluctuations of both speed of granule cell migration and cerebellar IGF-1 levels. Second, in vitro studies indicate that exogenous IGF-1 accelerates the migration of isolated granule cells through the activation of IGF-1 receptors. Third, in vivo studies reveal that inhibiting the IGF-1 receptors decelerates granule cell migration during light cycles (high IGF-1 levels) but does not alter migration during dark cycles (low IGF-1 levels). In contrast, stimulating the IGF-1 receptors accelerates granule cell migration during dark cycles (low IGF-1 levels) but does not alter migration during light cycles (high IGF-1 levels). These results suggest that during early postnatal development light stimuli control granule cell migration by altering the activity of IGF-1 receptors through modification of cerebellar IGF-1 levels.
- Subjects :
- Neurons
Multidisciplinary
Light
medicine.medical_treatment
Growth factor
Granule (cell biology)
Cell migration
Biology
Biological Sciences
Granule cell
Cell biology
Receptor, IGF Type 1
Insulin-like growth factor
Mice
medicine.anatomical_structure
Light Cycle
Cell Movement
medicine
Animals
Signal transduction
Receptor
Signal Transduction
Subjects
Details
- ISSN :
- 10916490
- Volume :
- 109
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Accession number :
- edsair.doi.dedup.....d96ae6e603f67f9f5b026c8bd4d6e2ed